2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Anti-infection
  3. HSP Fungal
  4. Hsp90-IN-47

Hsp90-IN-47 (Compound C15) 是一种 Hsp90 抑制剂、抗真菌 (Antifungal) 剂，对 Hsp90α 的 IC50 为 0.014 μM。Hsp90-IN-47 与 Fluconazole (HY-B0101) 联用，对 Fluconazole 耐受的白念珠菌 0304103 具有显著的协同抗真菌作用。Hsp90-IN-47 对急性髓系白血病和非小细胞肺癌具有抗肿瘤作用。

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Hsp90-IN-47

Hsp90-IN-47 Chemical Structure

CAS No. : 958888-13-6

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Hsp90-IN-47 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer[1].

IC50 & Target[1]

HSP90α

0.014 μM (IC50)

体外研究
(In Vitro)

HDAC/HSP90-IN-5 (3 h) 对 Hsp90α 具有强抑制作用，其 IC50 为 0.014 μM[1]。
HDAC/HSP90-IN-5 (48 h) 与 Fluconazole 联用，对 Fluconazole 耐受的白念珠菌 0304103 具有显著的协同抗真菌作用，其 FICI 为 0.063[1]。
HDAC/HSP90-IN-5 (一系列稀释浓度；48 h) 对 HEL 细胞、HL60 细胞和 A549 细胞具有增殖抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hsp90-IN-47 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HEL cell, HL60 cell, A549 cell
Concentration: series diluted concentrations
Incubation Time: 48 h
Result: Inhibited proliferation of HEL cells with an IC50 of 0.047±0.003 μM.
Inhibited proliferation of HL60 cells with an IC50 of 0.055±0.003 μM.
Inhibited proliferation of A549 cells with an IC50 of 0.65±0.14 μM.
Exerted strong proliferation inhibitory activity against leukemia cells HEL and HL60, and moderate proliferation inhibitory activity against lung cancer cell A549.
分子量

326.35

Formula

C17H18N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hsp90-IN-47 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hsp90-IN-47958888-13-6HSPFungalHeat shock proteinsHL60 cellsHEL cellslung cancerHDACHsp90αA549 cellsHsp90Candida albicans 0304103leukemiacandidiasisInhibitorinhibitorinhibit

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产品名称：
Hsp90-IN-47
目录号：
HY-186076
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