2. Epigenetics TGF-beta/Smad Apoptosis Cell Cycle/DNA Damage MAPK/ERK Pathway
  3. PKC Apoptosis Caspase PARP p38 MAPK JNK
  4. ICA-1S

ICA-1S 是一种特异性 PKC-ι 抑制剂。ICA-1S 可调控乳腺癌细胞中的 MAPK/JNK 信号通路、c-Jun 与 TNF-α。ICA-1S 可促进 c-Jun 降解并降低 c-Jun mRNA 水平。ICA-1S 可抑制乳腺癌细胞增殖。ICA-1S 可诱导乳腺癌细胞凋亡 (apoptosis)。ICA-1S 可用于乳腺癌相关研究。

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ICA-1S

ICA-1S Chemical Structure

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Customer Review

ICA-1S 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ICA-1S is a specific PKC-ι inhibitor. ICA-1S regulates the MAPK/JNK signaling pathway, c-Jun and TNF-α in breast cancer cells. ICA-1S promotes c-Jun degradation and reduces c-Jun mRNA levels. ICA-1S inhibits the proliferation of breast cancer cells. ICA-1S induces apoptosis of breast cancer cells. ICA-1S can be used in breast cancer-related research[1].

体外研究
(In Vitro)

ICA-1S (2.5-30 μM; 120 h) 可强效抑制 BT-549 和 MCF-7 乳腺癌细胞的增殖，经 5 天处理后其 IC50 值分别为 10 μM 和 20 μM[1]。
ICA-1S (10-20 μM; 120 h) 以 IC50 浓度处理 5 天后，可诱导 BT-549 (通过增加剪切型 Caspase 3 和剪切型 PARP) 和 MCF-7 (通过增加剪切型 PARP) 乳腺癌细胞发生凋亡[1]。
ICA-1S (10-20 μM (MCF-7); 120 h) 可下调 BT-549 和 MCF-7 乳腺癌细胞中的 PKC-ι、PKC-ζ 水平，但对 MCF-7 细胞无此作用[1]。
ICA-1S (10-20 μM; 120 h) 可抑制致癌性 MAPK/JNK 通路，降低 BT-549 和 MCF-7 乳腺癌细胞中磷酸化及总通路蛋白、c-Jun 和 TNF−α 的水平[1]。
ICA-1S (10-20 μM; 120 h) 可使 BT-549 乳腺癌细胞中的 c-Jun mRNA 水平降低 50%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ICA-1S 相关抗体:

Cell Proliferation Assay[1]

Cell Line: BT-549, MCF-7 breast cancer cell lines
Concentration: 2.5 μM, 5 μM, 10 μM, 20 μM, 30 μM
Incubation Time: 120 h, with treatments every 24 h
Result: Significantly reduced cell proliferation in both cell lines.
Achieved an IC50 of 10 μM, resulting in 45% inhibition for BT-549 cells.
Achieved an IC50 of 20 μM, resulting in 43% inhibition for MCF-7 cells.

Real Time qPCR[1]

Cell Line: BT-549, MCF-7 breast cancer cell lines
Concentration: 10 μM (BT-549); 20 μM (MCF-7)
Incubation Time: 120 h
Result: Reduced c-Jun mRNA levels by 50% in BT-549 cells compared to untreated controls.
Had no significant effect on c-Jun mRNA levels in MCF-7 cells.
分子量

240.26

Formula

C10H16N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ICA-1S 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICA-1SPKCApoptosisCaspasePARPp38 MAPKJNKProtein kinase Cpoly ADP ribose polymerase c-Jun N-terminal kinaseTNF-αMAPK/JNK signaling pathwaycleaved Caspase 3PKC-ζMCF-7breast cancer cellsc-JunPKC-ιBT-549apoptosisInhibitorinhibitorinhibit

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