2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase
  4. Indoluidin D

Indoluidin D 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对人源 DHODH 的 IC50 为 210 nM。Indoluidin D 可选择性抑制人源 DHODH 的活性，其诱导的效应可被乳清酸逆转。Indoluidin D 可促进髓系分化并抑制癌细胞增殖。Indoluidin D 可用于急性早幼粒细胞白血病的研究。

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Indoluidin D

Indoluidin D Chemical Structure

CAS No. : 2763081-61-2

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Indoluidin D 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Indoluidin D is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with a human DHODH IC50 of 210 nM. Indoluidin D selectively inhibits human DHODH activity, with induced effects rescuable by orotic acid. Indoluidin D promotes myeloid differentiation and inhibits cancer cell proliferation. Indoluidin D can be used for the research of acute promyelocytic leukemia[1].

体外研究
(In Vitro)

Indoluidin D (0.01-1000 nM; 96 h) 可诱导人早幼粒细胞白血病 HL-60 细胞发生髓系分化，其 EC50 为 10 nM，且该效应可被乳清酸特异性逆转[1]。
Indoluidin D (72 h) 可抑制多种人类癌细胞系的生长，对急性 T 细胞白血病 Jurkat 细胞的效力最强 (IC50 = 0.68 nM)，对正常胰腺 1B2C6/1C3D3 细胞和骨肉瘤 Saos-2/MG-63 细胞的活性最低[1]。
Indoluidin D (1-1000 nM; 30 min preincubation) 可抑制重组人源 DHODH/ΔTM 酶的活性，其 IC50 为 210 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indoluidin D 相关抗体:

Cell Differentiation Assay[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: 0, 10, 20, 30, 40 nM
Incubation Time: 96 h
Result: Potently induced myeloid differentiation of HL-60 cells, with an EC50 of 10 nM.
Induced expression of CD11b, a myeloid differentiation marker, in HL-60 cells.
Induced differentiation was rescued by addition of 1 mM orotic acid but not 1 mM dihydroorotic acid.

Cell Viability Assay[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: 0.01, 0.1, 1, 10, 100, 1000 nM
Incubation Time: 72 h
Result: Potently suppressed viability and proliferation of HL-60 cells, with an IC50 of 4.4 nM.
分子量

452.55

Formula

C28H28N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Indoluidin D 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indoluidin D2763081-61-2Dihydroorotate DehydrogenaseDHODHHeLa cellsorotic aciddihydroorotate dehydrogenaseacute promyelocytic leukemiahuman DHODHmyeloid differentiationnormal pancreatic 1B2C6/1C3D3 cellshuman promyelocytic leukemia HL-60 cellsosteosarcoma Saos-2 cellsacute T cell leukemia Jurkat cellsInhibitorinhibitorinhibit

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