2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Iprindole hydrochloride

Iprindole hydrochloride 是一种阿片受体 (opioid receptor) 激动剂，属于三环类抗抑郁剂。Iprindole hydrochloride 可缩短小鼠强迫游泳试验中的不动时间，而阿片拮抗剂 Naloxone (HY-17417A) 可逆转这一作用。Iprindole hydrochloride 与其降解抑制剂 (Thiorphan (HY-W013375) 或 Bestatin (HY-B0134)) 联用可进一步缩短小鼠不动时间。Iprindole hydrochloride 对猫的非快速眼动睡眠、觉醒或不确定睡眠期无显著影响。Iprindole hydrochloride 可诱导层状体形成，但自身不产生层状体。Iprindole hydrochloride 可用于抑郁症的研究。

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Iprindole hydrochloride

Iprindole hydrochloride Chemical Structure

CAS No. : 20432-64-8

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Iprindole hydrochloride 的其他形式现货产品:

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Other Forms of Iprindole hydrochloride:

Iprindole hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iprindole hydrochloride, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole hydrochloride shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole hydrochloride plus inhibitor of its degradation (Thiorphan (HY-W013375) or Bestatin (HY-B0134)) further decrease the immobility time. Iprindole hydrochloride does not significantly affect NREM sleep, wakefulness, or indeterminate sleep periods in cats. Iprindole hydrochloride induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression[1][2][3].

体外研究
(In Vitro)

Iprindole (0.1-10 μM；8 小时) hydrochloride 可诱导 L-2 细胞形成层状体。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iprindole hydrochloride 相关抗体:
体内研究
(In Vivo)

Iprindole (1-40 mg/kg；腹腔注射；单次给药) hydrochloride 在健康猫中给药剂量高达 40 mg/kg 时，对快速眼动 (REM) 睡眠、非快速眼动 (NREM) 睡眠、觉醒状态或不确定期均无显著影响[1]。
Iprindole hydrochloride (10-50 mg/kg；腹腔注射；单次给药) 可缩短雄性 ICR Swiss 小鼠强迫游泳试验中的不动时间[2]。
Iprindole hydrochloride (20 mg/kg；腹腔注射；单次给药) 在雄性 ICR Swiss 小鼠强迫游泳试验中的作用被阿片拮抗剂 Naloxone 逆转[2]。

Iprindole hydrochloride (20 mg/kg；腹腔注射；单次给药) 在雄性 ICR Swiss 小鼠强迫游泳试验中的作用被它的降解抑制剂 (Bestatin 或 Thiorphan) 增强[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Domestic cats[1]
Dosage: 1.0 mg/kg; 2.0 mg/kg; 5.0 mg/kg; 20 mg/kg; 40 mg/kg
Administration: i.p.; single dose
Result: Did not significantly reduce REM sleep compared to population standards.
Did not significantly affect NREM sleep, wakefulness, or indeterminate periods.
Animal Model: ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
Dosage: 10 mg/kg; 20 mg/kg; 50 mg/kg
Administration: i.p.; single dose
Result: Shortened the immobility time.
Animal Model: ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
Dosage: 20 mg/kg plus Naloxone (1 mg/kg)
Administration: i.p.; single dose
Result: Activity was reserved by the opiate antagonist Naloxone.
Animal Model: ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
Dosage: 10 mg/kg plus Bestatin or
Thiorphan(10 μg/kg)
Administration: i.p.; single dose
Result: Further decreased the immobility time.
分子量

320.90

Formula

C19H29ClN2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Iprindole hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iprindole20432-64-8Opioid ReceptorNREM sleepdepressionwakefulnessmonoamine oxidase inhibitoramphetamineREM sleeptricyclic antidepressantcatsnorepinephrineInhibitorinhibitorinhibit

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