2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. ITYR-DBRMD

ITYR-DBRMD 是一种 III 型脱碘酶 (DIO3) 抑制剂。ITYR-DBRMD 表现出类抗抑郁活性，并可缩短小鼠的摄食潜伏期。ITYR-DBRMD 可用于抑郁症的相关研究。

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ITYR-DBRMD

ITYR-DBRMD Chemical Structure

CAS No. : 1809339-61-4

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ITYR-DBRMD 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression[1].

体外研究
(In Vitro)

ITYR-DBRMD (Compouund 5) (0.5 μM; 48 h) 可降低 OVCAR3 细胞的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ITYR-DBRMD 相关抗体:

Cell Viability Assay[1]

Cell Line: OVCAR3 cells
Concentration: 0.5 μM
Incubation Time: 48 h
Result: Reduced cell numbers by microscopy.
体内研究
(In Vivo)

ITYR-DBRMD (Compound 5)(5 mg/kg；侧脑室注射；通过渗透微型泵持续输注) 在 BALB/c 小鼠的新环境摄食抑制试验中减少潜伏期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 8 weeks old)[1]
Dosage: 5 mg/kg
Administration: i.c.v.; continuous infusion via osmotic minipump
Result: Reduced the latency to feed in the novelty suppressed feeding test.
分子量

670.82

Formula

C13H7Br2I2NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ITYR-DBRMD 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITYR-DBRMD1809339-61-4Thyroid Hormone ReceptorTHRType III deiodinaseBALB/c miceT3T2depressiondiiodothyroninetriiodothyroninemiceDIO3novelty suppressed feeding testInhibitorinhibitorinhibit

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产品名称：
ITYR-DBRMD
目录号：
HY-182688
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