2. Anti-infection
  3. Bacterial
  4. KF-22

KF-22 是一种抗菌肽，对革兰氏阴性和革兰氏阳性菌均表现出抗菌活性。KF-22 具有广谱强效的抗多重耐药细菌活性和低毒性。KF-22 可用于感染方面的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

KF-22

KF-22 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

KF-22 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KF-22 is an antimicrobial peptide that exhibits antimicrobial activity against both Gram-negative and Gram-positive bacteria. KF-22 demonstrates broad-spectrum, potent activity against multidrug-resistant bacteria with low toxicity. KF-22 can be used in research related to infections[1].

体外研究
(In Vitro)

KF-22 (18-24 小时) 对 21 株多重耐药革兰氏阴性菌和革兰氏阳性菌具有强效广谱抗菌活性，其 MIC 范围为 1.25 至 5 μg/mL[1]。
KF-22 (0-320 μg/mL；1-24 小时) 对小鼠红细胞的溶血活性较低，在浓度 ＞ 120 μg/mL 时对 HEK 293 细胞具有中等毒性，而对 RAW 264.7 细胞的细胞毒性更低[1]。
KF-22 (1-10 μg/mL) 以浓度依赖的方式破坏 A. baumannii ATCC 19606 和 S. aureus ATCC 25923 的细胞质膜电位[1]。
KF-22 (0-20 μg/mL；1 小时) 可呈剂量依赖性破坏 A. baumannii ATCC 19606 和 S. aureus ATCC 25923 的外膜和细胞质膜[1]。
KF-22 (0-20 μg/mL；24 小时) 可呈剂量依赖性抑制 A. baumannii ATCC 19606 和 S. aureus ATCC 25923 的生物膜形成，并清除其预先形成的生物膜[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KF-22 相关抗体:
体内研究
(In Vivo)

KF-22 (5-10 mg/kg；腹腔注射；每日 1 次；连续 3 天) 可提高感染 A. baumannii ATCC 19606 的小鼠存活率[1]。
KF-22 (2-8 mg/kg；腹腔注射；感染后 1 小时单剂量给药) 在感染 A. baumannii ATCC 19606 的中性粒细胞减少症小鼠中具有抗菌作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (female, 6-8 weeks old, 18 ± 2 g, intraperitoneally infected with A. baumannii ATCC 19606)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.; daily; 3 days
Result: Achieved 62.5% survival rate over 7 days at 5 mg/kg.
Achieved 75% survival rate over 7 days at 10 mg/kg.
Animal Model: C57BL/6J mice (female, 6-8 weeks old, 18 ± 2 g, neutropenia induced by cyclophosphamide (HY-17420), then intraperitoneally infected with Acinetobacter baumannii ATCC 19606)[1]
Dosage: 2 mg/kg; 4 mg/kg; 8 mg/kg
Administration: i.p.; single dose 1 hour post-infection
Result: Reduced bacterial load in kidney, liver, lung, and spleen.
Significantly decreased proinflammatory cytokine (TNF-α, IL-1β) production in kidney and lung homogenates.
Showed no significant pathological changes in kidney, liver, lung, or spleen via H&E staining.
分子量

2882.54

Formula

C137H229N41O27
Sequence

Lys-Phe-Phe-Arg-Lys-Leu-Lys-Lys-Ser-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg
Sequence Shortening

KFFRKLKKSFKRIVQRIKDFLR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KF-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KF-22KF22KF 22BacterialRAW 264.7 cellsGram-negative pathogensAcinetobacter baumannii ATCC 19606mouse infection modelsGram-positive pathogensneutropenic mice miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
KF-22
目录号：
HY-P11634
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z