2. Cell Cycle/DNA Damage Cytoskeleton PI3K/Akt/mTOR
  3. Microtubule/Tubulin Akt
  4. KS-99

KS-99 是一种兼具微管蛋白 (tubulin) 聚合与 Akt 通路抑制活性的双重抑制剂。KS-99 抑制癌细胞增殖并诱导癌细胞凋亡 (apoptosis)。KS-99 可用于结直肠癌、乳腺癌、肺上皮癌、黑色素瘤的相关研究。

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KS-99

KS-99 Chemical Structure

CAS No. : 1344698-28-7

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KS-99 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KS-99 is a dual inhibitor with both tubulin polymerization inhibitory activity and Akt pathway inhibitory activity. KS-99 inhibits cancer cell proliferation and induces cancer cell apoptosis. KS-99 can be used in research related to colorectal cancer, breast cancer, lung epithelial cancer and melanoma[1].

体外研究
(In Vitro)

KS-99 (Compound 11) (0.5-50 μM; 48 h) 可强效抑制 HT29、A549 和 UACC903 癌细胞的活力，其 IC50 值分别为 1.14 μM、2.53 μM 和 2.23 μM；它对 MCF-7 细胞的活性显著较低，且在处理 48 h 后对正常 MEF 细胞的毒性较低[1]。
KS-99 (1.25-5.0 μM; 24 h) 可在人结肠癌细胞 HT29 中诱导剂量依赖性凋亡，在 5.0 μM 处理 24 h 后，有 66.98%的细胞发生凋亡[1]。
KS-99 (1.25-5.0 μM; 24 h) 可剂量依赖性地激活人结肠癌细胞 HT29 中的 caspase-3/7，证实其可诱导细胞凋亡通路[1]。
KS-99 (5 μM; 48 h) 可诱导人结肠癌细胞 HT29 发生 DNA 片段化[1]。
KS-99 (1-2 μM; 24 h) 可下调 HT29 人结肠癌细胞中总 Akt 蛋白水平，并在 1 μM 和 2 μM 浓度处理 24 h 后完全消除 Akt 的磷酸化，作为 Akt 通路的强效抑制剂[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KS-99 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human colorectal cancer HT29 cells, human breast cancer MCF-7 cells, human lung epithelial carcinoma A549 cells, human melanoma UACC903 cells, mouse embryonic fibroblasts (MEF) cells
Concentration: 0.5-50 μM
Incubation Time: 48 h
Result: Exhibited an IC50 of 1.14 μM against HT29 cells, 24.70 μM against MCF-7 cells, 2.53 μM against A549 cells, 2.23 μM against UACC903 cells, and an IC50 > 20 μM against MEF cells.

Apoptosis Analysis[1]

Cell Line: human colorectal cancer HT29 cells
Concentration: 1.25 μM, 2.5 μM, 5.0 μM
Incubation Time: 24 h
Result: Induced apoptosis in 11.47% of HT29 cells at 1.25 μM, 39.46% at 2.5 μM, and 66.98% at 5.0 μM.

Apoptosis Analysis[1]

Cell Line: human colorectal cancer HT29 cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Resulted in a significant number of TUNEL-positive HT29 cells, indicating DNA fragmentation as a hallmark of apoptosis.

Western Blot Analysis[1]

Cell Line: human colorectal cancer HT29 cells
Concentration: 1 μM, 2 μM
Incubation Time: 24 h
Result: Reduced Akt protein levels and strongly suppressed the phosphorylation of Akt, eliminating detectable phosphorylated Akt at 1 μM and 2 μM.
分子量

466.15

Formula

C17H10Br2N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KS-99 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS-991344698-28-7KS99KS 99Microtubule/TubulinAktPKBProtein kinase Bmelanoma cancerHT29breast cancerapoptosisUACC903colorectal cancerlung epithelial carcinomatubulin polymerizationA549Akt pathwayInhibitorinhibitorinhibit

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