2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel Calcium Channel
  4. KS0365

KS0365 是一种选择性 TRPV3 激活剂，其 EC50 为 5.08 μM。KS0365 不激活 TRPV2 或 TRPV4 通道。KS0365 触发 [Ca2+]i 的增加，并加速角质形成细胞的迁移。KS0365 可用于皮肤伤口愈合受损相关研究。

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KS0365

KS0365 Chemical Structure

CAS No. : 1689577-22-7

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KS0365 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KS0365 is a selective TRPV3 agonist with an EC50 of 5.08 μM. KS0365 does not activate TRPV2 or TRPV4 channels. KS0365 triggers an increase in [Ca2+]i and accelerates keratinocyte migration. KS0365 can be used in studies related to impaired skin wound healing[1].

IC50 & Target[1]

TRPV3

5.08 μM (EC50)

体外研究
(In Vitro)

KS0365 (0.1-100 μM) 可强效且选择性地激活 HEKmTRPV3-CFP 细胞中的重组小鼠 TRPV3，其 EC50 为 5.08 μM，可诱导持续的 [Ca2+]ᵢ 升高，且在 10 μM 浓度下无显著脱靶效应[1]。
KS0365 (0.8-12.5 μM HEK cells; 10-50 μM m308k cells; 24 h) 可诱导 TRPV3 依赖性的代谢活性变化：它会降低过表达 TRPV3 的 HEKmTRPV3-CFP 细胞的代谢活性，并在 m308k Mus musculus (小家鼠) 角质形成细胞中产生双相效应，10 μM 时通过 TRPV3 介导代谢活性升高，50 μM 时则出现脱靶毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KS0365 相关抗体:

Cell Viability Assay[1]

Cell Line: HEKmTRPV3-CFP cells, parental HEK293 cells, m308k mouse keratinocytes
Concentration: 0.8-12.5 μM (HEK cells); 10-50 μM (m308k cells)
Incubation Time: 24 h
Result: Caused a concentration-dependent decrease in metabolic activity in HEKmTRPV3-CFP cells, which was reversed by co-treatment with 10 μM ruthenium red.
Showed no decrease in metabolic activity in parental HEK293 cells.
Exhibited a biphasic effect in m308k cells: 10 μM and 25 μM slightly but significantly increased metabolic activity (126.5% and 107.8% of untreated control, respectively), while 50 μM drastically decreased metabolic activity.
Inhibited the pro-metabolic effect of 10 μM KS0365 by 10 μM ruthenium red, but effects of 25 μM and 50 μM KS0365 were unaffected by ruthenium red.
分子量

250.76

Formula

C15H19ClO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KS0365 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KS03651689577-22-7KS 0365KS-0365TRP ChannelCalcium ChannelTransient receptor potential channelsCa2+ channelsCa channelsHEKmTRPV3-CFP cellsionic currentsTRPA1HEK293 cellsm308k mouse keratinocytesEGFintracellular calciumskin wound healingkeratinocytesTRPV3Inhibitorinhibitorinhibit

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HY-186172
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