2. Immunology/Inflammation
  3. FLAP
  4. L 689037

L 689037 是一种白三烯 (LT) 生物合成抑制剂，也是5-脂氧合酶激活蛋白 (FLAP) 结合剂。[¹²⁵I]-L 691,831 被用作一个标准探针，来精确定位决定抑制剂与 FLAP 结合的关键结构域。L 689037 可用于哮喘和炎症性肠病的研究。

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L 689037

L 689037 Chemical Structure

CAS No. : 136668-50-3

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L 689037 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L 689037 is a leukotriene biosynthesis (LT) inhibitor and a 5-lipoxygenase-activating protein (FLAP) binder. [125I]-L 691,831 serves as a standard probe to precisely locate the key structural domains that determine the binding of inhibitors to FLAP. L 689037 can be used in the research of asthma and inflammatory bowel disease[1].

体外研究
(In Vitro)

L 689037 可与 [125I]-L-691,831 竞争结合 COS-7 细胞膜上表达的野生型及特定突变型人 5-脂氧合酶激活蛋白，其 IC50 值范围为 2 nM 至 41 nM；而对于残基 48-61 缺失的突变体，其结合作用无法检测到[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L 689037 相关抗体:
分子量

597.14

Formula

C36H37ClN2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L 689037 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L 689037136668-50-3L689037L-689037FLAP5-lipoxygenase-activating protein5-LO activating proteinCOS-7 cell membraneshuman 5-lipoxygenase-activating proteinleukotriene biosynthesisasthmainflammatory bowel diseaseInhibitorinhibitorinhibit

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