2. Others Metabolic Enzyme/Protease Neuronal Signaling
  3. Fluorescent Dye Aminopeptidase Monoamine Oxidase
  4. L&M-D-MR

L&M-D-MR 是一种高特异性、带有亮氨酸氨基肽酶 (LAP) 和单胺氧化酶 (MAO) 响应基团的荧光型 “AND” 逻辑探针。L&M-D-MR 需要 LAP 和 MAO 同时存在才能触发分子内环化、释放荧光团并激活荧光。若仅有单一酶作用时，L&M-D-MR 仅会产生极微弱的信号。L&M-D-MR 能在活细胞和小鼠模型中进行生物成像，还能通过血液样本或试纸有效区分不同的肝病亚型。L&M-D-MR 被广泛应用于肝硬化、乙型肝炎以及药物性肝损伤等相关研究中。

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L&M-D-MR

L&M-D-MR Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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L&M-D-MR 相关抗体

Top Publications Citing Use of Products

查看 Aminopeptidase 亚型特异性产品:

查看所有亚型
CD13 LTA4H

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L&M-D-MR is a highly specific fluorescent "AND" logic probe with response moieties for leucine aminopeptidase (LAP) and monoamine oxidase (MAO). The coexistence of both LAP and MAO is required for L&M-D-MR to trigger intramolecular cyclization, release fluorophores and activate fluorescence. In the presence of only a single enzyme, L&M-D-MR generates only an extremely weak signal. L&M-D-MR enables bioimaging in living cells and mouse models, and can effectively distinguish different subtypes of liver diseases via blood samples or test strips. L&M-D-MR is widely used in studies related to liver cirrhosis, hepatitis B and drug-induced liver injury[1][2][3][4].
体外研究
(In Vitro)

L&M-D-MR (10 μM; 10 h) 可在过表达 MAO 和 LAP 的 HepG2 肝癌细胞中产生强烈的选择性荧光，HepG2 细胞与 QSG-7701 正常肝细胞的荧光强度比值高达 13.0 倍，且经 MAO 或 LAP 抑制剂预处理后，该响应会被完全消除[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L&M-D-MR 相关抗体:
分子量

1015.12

Formula

C54H62N8O12
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L&M-D-MR 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L&M-D-MRFluorescent DyeAminopeptidaseMonoamine OxidaseMAOleucine aminopeptidasehepatopathy subtypesQSG-7701 normal liver cellsbioimagingmouse modelshepatitis Bliver cirrhosismonoamine oxidasedrug-induced liver injuryHepG2 liver cancer cellsInhibitorinhibitorinhibit

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