2. Immunology/Inflammation Apoptosis
  3. LAG-3 TNF Receptor
  4. LAGi-DEL

LAGi-DEL 是一种 LAG-3 抑制剂，在表面等离子体共振 (SPR) 实验和微量热泳动 (MST) 实验中的 Kd 值分别为 97.33 nM 和 271 nM。LAGi-DEL 阻断 LAG-3/MHC-II 相互作用，其 EC50 为 138 nM。LAGi-DEL 能够恢复 T 细胞活化、提升 IFN-γ 分泌并促进免疫介导的杀伤作用。LAGi-DEL 可用于急性髓系白血病、肺癌、黑色素瘤的研究。

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LAGi-DEL

LAGi-DEL Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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LAGi-DEL 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LAGi-DEL is a LAG-3 inhibitor, with Kd values of 97.33 nM and 271 nM in surface plasmon resonance (SPR) assay and microscale thermophoresis (MST) assay, respectively. LAGi-DEL blocks the LAG-3/MHC-II interaction, with an EC50 of 138 nM. LAGi-DEL restores T cell activation, enhances IFN-γ secretion and promotes immune-mediated cytotoxicity. LAGi-DEL can be used in the research of acute myeloid leukemia, lung cancer and melanoma[1].

体外研究
(In Vitro)

LAGi-DEL (10 μM; 24 h) 可恢复 T 细胞活化、提升 IFN-γ 分泌，并在 PBMC 共培养模型中促进免疫介导的 THP-1 人急性髓系白血病细胞杀伤作用[1]。
LAGi-DEL (10 μM; 24 h) 可恢复 T 细胞活化，提升 IFN-γ 分泌，并在 PBMC 共培养模型中促进免疫介导的 A549 人肺癌细胞杀伤作用[1]。
LAGi-DEL 具有良好的类药属性，包括高水溶性、中等通透性、可接受的代谢与血浆稳定性、对正常细胞的低细胞毒性、可忽略的 hERG 和 CYP 风险，且无诱变活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LAGi-DEL 相关抗体:
分子量

530.59

Formula

C28H26N4O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LAGi-DEL 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAGi-DELLAG-3TNF ReceptorLymphocyte activation gene-3CD223Tumor Necrosis Factor ReceptorTNFRmelanomaTHP-1IFN-γT cellPBMCA549MHC-IIlung canceracute myeloid leukemiaInhibitorinhibitorinhibit

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产品名称：
LAGi-DEL
目录号：
HY-181685
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