2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Leukotuximab

Leukotuximab  (Synonyms: ART-140; DNP-001; EGX-040)

目录号: HY-P992058
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技术支持

Leukotuximab (ART-140; EGX-040) 是一种抗 JL1 单克隆抗体和抗白血病试剂。Leukotuximab 靶向 CD43 的 JL1 表位，对 JL1 阳性白血病细胞发挥细胞毒作用。除胸腺细胞和部分骨髓单个核细胞外，Leukotuximab 对多数正常组织无损伤。Leukotuximab 可用于急性髓系白血病 (AML)、急性淋巴细胞白血病、骨髓增生异常综合征的研究。

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Leukotuximab

Leukotuximab Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Leukotuximab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leukotuximab (ART-140; EGX-040) is an anti-JL1 mAb and an anti-leukemic agent. Leukotuximab targets the JL1 epitope of CD43 and exerts cytotoxic effects on JL1-positive leukemia cells. Except for thymocytes and some bone marrow mononuclear cells, Leukotuximab causes no damage to most normal tissues. Leukotuximab can be used in the research of acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome[1][2].

反应种属

Human
体内研究
(In Vivo)

JL1 抗原在超过半数 AML 患者的白血病细胞上表达。抗 JL1 抗体 Leukotuximab 已在韩国用于急性白血病案例的 I 期研究[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

6693  [NCBI]

Accession
靶点

CD43/Leukosialin
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Leukotuximab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LeukotuximabART-140 DNP-001 EGX-040ART140ART 140DNP001DNP 001DNP-001EGX040EGX 040EGX-040Transmembrane Glycoproteinthymocytesacute lymphoblastic leukemiabone marrow mononuclear cellsacute myeloid leukemiaJL1CD43myelodysplastic syndromeJL1-positive leukemic cellsInhibitorinhibitorinhibit

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