2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker
  4. Mal-Val-Lys-PAB-CBI-PBD dimer

Mal-Val-Lys-PAB-CBI-PBD dimer 是一种 ADC-药物连接子偶联物 (Drug-Linker Conjugates for ADC)。Mal-Val-Lys-PAB-CBI-PBD dimer 由 ADC 细胞毒素 CBI-PBD 二聚体和连接子 Mal-Val-Lys-PAB 组成。Mal-Val-Lys-PAB-CBI-PBD dimer 在富含 A-T 的 DNA 小沟腺嘌呤残基处表现出烷基化活性，破坏 DNA 完整性。Mal-Val-Lys-PAB-CBI-PBD dimer 可诱导癌细胞生长抑制和细胞死亡。Mal-Val-Lys-PAB-CBI-PBD dimer 可用于癌症相关研究。

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Mal-Val-Lys-PAB-CBI-PBD dimer

Mal-Val-Lys-PAB-CBI-PBD dimer Chemical Structure

CAS No. : 1661824-39-0

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Mal-Val-Lys-PAB-CBI-PBD dimer 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer[1].

体外研究
(In Vitro)

Mal-Val-Lys-PAB-CBI-PBD dimer (Compound CBI-PBD dimer- linker (B)) 可用于合成靶向 HER2 和靶向 CD22 的 ADCs，可在体外介导 HER2 阳性和 CD22 阳性癌细胞中抗原依赖性的生长抑制与细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-Val-Lys-PAB-CBI-PBD dimer 相关抗体:
分子量

1289.90

Formula

C67H85ClN10O14
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mal-Val-Lys-PAB-CBI-PBD dimer 相关分类

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Keywords:

Mal-Val-Lys-PAB-CBI-PBD dimer1661824-39-0Drug-Linker Conjugates for ADCDNA Alkylator/CrosslinkerCD22-positive cancer cellsA-T-rich DNA minor groove adenine residuesCD22cancer cellcancerHER2-positive cancer cellstumor xenograftantibody-drug conjugatesDNAHER2Inhibitorinhibitorinhibit

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