2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mal-VC-PAB-seco-CBI-PBD dimer

Mal-VC-PAB-seco-CBI-PBD dimer 是 一种 drug-linker conjugate。Mal-VC-PAB-seco-CBI-PBD dimer 融合了两种不同类型化合物的 DNA 损伤作用：开环环丙烷苯并吲哚啉 (seco-CBI) 与吡咯并苯二氮䓬 (PBD)。Mal-VC-PAB-seco-CBI-PBD dimer 通过可被组织蛋白酶 B 裂解的缬氨酸 - 丙氨酸 (VC) 连接臂进行连接，依靠单克隆抗体实现靶向递送。Mal-VC-PAB-seco-CBI-PBD dimer 可用于癌症研究。

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Mal-VC-PAB-seco-CBI-PBD dimer

Mal-VC-PAB-seco-CBI-PBD dimer Chemical Structure

CAS No. : 1661823-95-5

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Mal-VC-PAB-seco-CBI-PBD dimer 相关抗体

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查看 Drug-Linker Conjugates for ADC 亚型特异性产品:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mal-VC-PAB-seco-CBI-PBD dimer is a highly active drug-linker conjugate. Mal-VC-PAB-seco-CBI-PBD dimer integrates the DNA-damaging effects of two distinct types of compounds: seco-cyclopropabenzindoline (seco-CBI) and pyrrolobenzodiazepine (PBD). Mal-VC-PAB-seco-CBI-PBD dimer is linked via a valine-alanine (VC) linker cleavable by cathepsin B and achieves targeted delivery relying on monoclonal antibodies. Mal-VC-PAB-seco-CBI-PBD dimer is applicable for cancer research[1].

体外研究
(In Vitro)

包含 Mal-VC-PAB-seco-CBI-PBD 二聚体的 ADC 可诱导抗原依赖性细胞毒性，抑制 HER2 阳性和 CD22 阳性癌细胞系的生长并使其死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-VC-PAB-seco-CBI-PBD dimer 相关抗体:
分子量

1130.72

Formula

C60H72ClN9O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mal-VC-PAB-seco-CBI-PBD dimer 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Mal-VC-PAB-seco-CBI-PBD dimer1661823-95-5Drug-Linker Conjugates for ADCADC PayloadcancerInhibitorinhibitorinhibit

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Mal-VC-PAB-seco-CBI-PBD dimer
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