2. Others PI3K/Akt/mTOR
  3. Drug Derivative Akt
  4. MARY15

MARY15 是基于吡啶基哌嗪的 MARY1 衍生物。MARY15 可激活解偶联线粒体呼吸，并上调肾近端小管细胞中 p-AKT (S473) 的磷酸化水平。

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MARY15

MARY15 Chemical Structure

CAS No. : 3107758-65-3

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MARY15 相关抗体

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MARY15 is a pyridinylpiperazine-based derivative of MARY1. MARY15 activates uncoupled mitochondrial respiration and upregulates p-AKT (S473) phosphorylation in renal proximal tubule cells[1].

体外研究
(In Vitro)

MARY15 (30 nM; 24 h) 激活肾近端小管细胞中解偶联的线粒体呼吸，如 FCCP-OCR 所测量[1]。
MARY15 (30 nM; 1 h) 上调肾近端小管细胞中 p-AKT (S473) 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MARY15 相关抗体:

Western Blot Analysis[1]

Cell Line: Renal proximal tubule cells (RPTCs)
Concentration: 30 nM
Incubation Time: 1 h
Result: Significantly increased phosphorylation levels of AKT at Ser473.
分子量

377.36

Formula

C19H18F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MARY15 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MARY153107758-65-3MARY 15MARY-15Drug DerivativeAktDrug derivativePKBProtein kinase Brenal proximal tubule cellsuncoupled mitochondrial respirationmitochondrial oxygen consumption ratep-AKT (S473)Inhibitorinhibitorinhibit

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HY-17684
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