2. Academic Validation
  3. Highly potent PDE4 inhibitors with therapeutic potential

Highly potent PDE4 inhibitors with therapeutic potential

  • Bioorg Med Chem Lett. 2004 Jan 5;14(1):207-10. doi: 10.1016/j.bmcl.2003.09.087.
Hiroshi Ochiai 1,  Tazumi Ohtani,  Akiharu Ishida,  Kensuke Kusumi,  Masashi Kato,  Hiroshi Kohno,  Katuya Kishikawa,  Takaaki Obata,  Hisao Nakai,  Masaaki Toda
Affiliations

Affiliation

  • 1 Minase Research Institute, Ono Pharmaceutical Co. Ltd, 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan.
PMID: 14684329 DOI: 10.1016/j.bmcl.2003.09.087
Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

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