2. Academic Validation
  3. Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis

Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis

  • Phytother Res. 2007 Apr;21(4):386-90. doi: 10.1002/ptr.2081.
C Bayet 1,  C Fazio,  N Darbour,  O Berger,  I Raad,  A Chaboud,  C Dumontet,  D Guilet
Affiliations

Affiliation

  • 1 Université Claude Bernard Lyon 1, Laboratoire de Pharmacognosie, Faculté de Pharmacie, 8 avenue Rockefeller, 69373 Lyon Cedex 8, France.
PMID: 17236173 DOI: 10.1002/ptr.2081
Abstract

Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five Coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein.

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