2. Academic Validation
  3. The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon

The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon

  • J Nat Prod. 1991 Jul-Aug;54(4):1077-81. doi: 10.1021/np50076a024.
Y C Wu 1,  C Y Duh,  F R Chang,  G Y Chang,  S K Wang,  J J Chang,  D R McPhail,  A T McPhail,  K H Lee
Affiliations

Affiliation

  • 1 School of Pharmacy, Department of Microbiology, Kaohsiung Medical College, Taiwan, Republic of China.
PMID: 1791473 DOI: 10.1021/np50076a024
Abstract

The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.

Figures
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