2. Academic Validation
  3. Small molecules targeting p53 to improve antitumor therapy

Small molecules targeting p53 to improve antitumor therapy

  • Mini Rev Med Chem. 2008 Aug;8(9):856-68. doi: 10.2174/138955708785132774.
G L Beretta 1,  L Gatti,  V Benedetti,  P Perego,  F Zunino
Affiliations

Affiliation

  • 1 Department of Experimental Oncology and Laboratories, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian 1, Milan, Italy. giovanni.beretta@istitutotumori.mi.it
PMID: 18691143 DOI: 10.2174/138955708785132774
Abstract

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

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