2. Academic Validation
  3. Biological evaluation of secondary metabolites from the roots of Myrica adenophora

Biological evaluation of secondary metabolites from the roots of Myrica adenophora

  • Phytochemistry. 2014 Jul:103:89-98. doi: 10.1016/j.phytochem.2014.04.003.
Ya-Chih Ting 1,  Horng-Huey Ko 2,  Hui-Chun Wang 1,  Chien-Fang Peng 3,  Hsun-Shuo Chang 4,  Pei-Chen Hsieh 4,  Ih-Sheng Chen 5
Affiliations

Affiliations

  • 1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
  • 2 Department of Fragrance and Cosmetics Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
  • 3 Biomedical Laboratory Science and Biotechnology, College of Health Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
  • 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
  • 5 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC. Electronic address: m635013@kmu.edu.tw.
PMID: 24810013 DOI: 10.1016/j.phytochem.2014.04.003
Abstract

Bioassay-guided fractionation of the roots of Myrica adenophora led to isolation of 24 known compounds and hitherto unknown compounds, including three A-type proanthocyanidins [adenodimerins A-C], two esters of sucrose [myricadenins A and B ], and the phenolic glycoside 6'-O-galloyl orbicularin. Spectroscopic analyses were used to determine their structures. Adenodimerin A, myricananin C, and myricetin showed strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities, with SC50 values of 7.9, 16.3, and 15.9 μM, respectively. Adenodimerin A, myricanone, myricananin C, (-)-myricanol, myricanol 11-O-β-D-glucopyranoside, and myricetin showed stronger 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activities than the positive control, with SC50 values of 7.5, 19.6, 12.0, 22.3, 19.6, and 15.6 μM, respectively. 5-Deoxymyricanone, porson, 12-hydroxymyricanone (-)-myricanol, and (+)-galeon exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 25.8, 40.0, 35.8, 30.0, and 15.0 μg/mL, respectively. Myricadenin A, myricanone, myricananin C, and (-)-myricanol exhibited anti-inflammatory activities in the iNOS assay with EC50 values of 18.1, 1.00, 13.0, and 7.5 μM, respectively.

Keywords

Anti-inflammatory activity; Anti-oxidant activity; Anti-tubercular activity; Diarylheptanoid; Myrica adenophora; Myricaceae; Proanthocyanidin; Root.

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