2. Academic Validation
  3. The constituents of Michelia compressa var. formosana and their bioactivities

The constituents of Michelia compressa var. formosana and their bioactivities

  • Int J Mol Sci. 2014 Jun 17;15(6):10926-35. doi: 10.3390/ijms150610926.
Yu-Yi Chan 1,  Shin-Hun Juang 2,  Guan-Jhong Huang 3,  Yu-Ren Liao 4,  Yu-Fon Chen 5,  Chia-Che Wu 6,  Hui-Ting Chang 7,  Tian-Shung Wu 8
Affiliations

Affiliations

  • 1 Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. yuyichan@mail.stust.edu.tw.
  • 2 Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 40402, Taiwan. paul@mail.cmu.edu.tw.
  • 3 Department of Pharmacy, China Medical University, Taichung 40402, Taiwan. gjhuang@mail.cmu.edu.tw.
  • 4 Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. truthloveroy@yahoo.com.tw.
  • 5 Department of Life Sciences, National Cheng Kung University, Tainan 70101, Taiwan. yufons@gmail.com.
  • 6 School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. ujin1205@gmail.com.
  • 7 School of Forestry and Resource Conservation, National Taiwan University, Taipei 10617, Taiwan. chtchang@ntu.edu.tw.
  • 8 Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan. tswu@mail.ncku.edu.tw.
PMID: 24941253 DOI: 10.3390/ijms150610926
Abstract

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and Anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5±0.3 and 9.6±0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z