2. Academic Validation
  3. 7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon

7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon

  • Sci Rep. 2015 Jul 29:5:12546. doi: 10.1038/srep12546.
Shogo Haraguchi 1,  Yuzo Yamamoto 2,  Yuko Suzuki 3,  Joon Hyung Chang 3,  Teppei Koyama 3,  Miku Sato 3,  Masatoshi Mita 4,  Hiroshi Ueda 5,  Kazuyoshi Tsutsui 3
Affiliations

Affiliations

  • 1 1] Department of Biology and Center for Medical Life Science, Waseda University, Tokyo, Japan [2] Department of Biology, Tokyo Gakugei University, Tokyo, Japan.
  • 2 1] Field Science Center for Northern Biosphere, Hokkaido University, Hokkaido, Japan [2] Current address: Demonstration Laboratory, Marine Ecology Research Institute, Niigata, Japan.
  • 3 Department of Biology and Center for Medical Life Science, Waseda University, Tokyo, Japan.
  • 4 Department of Biology, Tokyo Gakugei University, Tokyo, Japan.
  • 5 Field Science Center for Northern Biosphere, Hokkaido University, Hokkaido, Japan.
PMID: 26220247 DOI: 10.1038/srep12546
Abstract

Salmon migrate upstream against an opposing current in their natal river. However, the molecular mechanisms that stimulate upstream migratory behavior are poorly understood. Here, we show that 7α-hydroxypregnenolone (7α-OH PREG), a newly identified neuronal modulator of locomotion, acts as a key factor for upstream migration in salmon. We first identified 7α-OH PREG and Cytochrome P450 7α-hydroxylase (P4507α), a steroidogenic enzyme producing 7α-OH PREG, in the salmon brain and then found that 7α-OH PREG synthesis in the brain increases during upstream migration. Subsequently, we demonstrated that 7α-OH PREG increases upstream migratory behavior of salmon. We further found that 7α-OH PREG acts on dopamine neurons in the magnocellular preoptic nucleus during upstream migration. Thus, 7α-OH PREG stimulates upstream migratory behavior through the dopaminergic system in salmon. These findings provide new insights into the molecular mechanisms of fish upstream migration.

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