2. Academic Validation
  3. Monoterpene indole alkaloids from Rhazya stricta

Monoterpene indole alkaloids from Rhazya stricta

  • Fitoterapia. 2018 Jul:128:1-6. doi: 10.1016/j.fitote.2018.04.018.
Abrar Ahmed 1,  Wei Li 1,  Fang-Fang Chen 1,  Jun-Sheng Zhang 1,  Ya-Qi Tang 1,  Lin Chen 1,  Gui-Hua Tang 2,  Sheng Yin 1
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
  • 2 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address: tanggh5@mail.sysu.edu.cn.
PMID: 29723561 DOI: 10.1016/j.fitote.2018.04.018
Abstract

Twenty-seven Monoterpene Indole Alkaloids (MIAs) including three new ones were isolated from the plant of Rhazya stricta. Their structures were elucidated by analyses of HRMS and NMR data. Secopleiocarpamine A (1) represents a novel 2,3-seco pleiocarpamine type MIA possessing a cyano group. A possible biosynthetic pathway for 1 was postulated. All compounds were evaluated for their inhibitory activities against six Candida strains, and the results showed that 2, 5, 12, 21, 23, and 27 exhibited moderate inhibitory activities with MIC values ranging from 3.125 to 50 μg/mL.

Keywords

Antifungal activity; Apocynaceae; Monoterpene indole alkaloids; Rhazya stricta.

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