2. Academic Validation
  3. Diverse flavonoids from the roots of Millettia brandisiana

Diverse flavonoids from the roots of Millettia brandisiana

  • Phytochemistry. 2019 Jun:162:157-164. doi: 10.1016/j.phytochem.2019.03.013.
Phanruethai Pailee 1,  Chulabhorn Mahidol 2,  Somsak Ruchirawat 3,  Vilailak Prachyawarakorn 4
Affiliations

Affiliations

  • 1 Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
  • 2 Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand; Chemical Biology Program, Chulabhorn Graduate Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
  • 3 Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand; Chemical Biology Program, Chulabhorn Graduate Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok 10400, Thailand.
  • 4 Laboratory of Natural Products, Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. Electronic address: vilailak@cri.or.th.
PMID: 30925376 DOI: 10.1016/j.phytochem.2019.03.013
Abstract

The phytochemical investigation for the constituents of the roots of Millettia brandisiana, using bioassay guided fractionation, resulted in the isolation of five previously undescribed (namely brandisianones A-E) and twenty-six known Flavonoids. Their chemical structures were determined using a combination of NMR, MS, IR, optical rotation and CD analysis, as well as comparison with the literature data. The crude extract as well as the isolated compounds were evaluated in various biological assays for their cytotoxicity against a panel of human Cancer cell lines, potential inhibitory activity against aromatase, and antioxidant property using the oxygen radical absorbance capacity (ORAC) with an aim to search for leads and develop them to drug candidates in our drug discovery effort, we identified three bioactive Flavonoids from M. brandisiana which could be further developed into a potential chemopreventive (antiaromatase) agent against breast Cancer.

Keywords

Antiaromatase; Cytotoxicity; Fabaceae; Flavonoids; Millettia brandisiana.

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