2. Academic Validation
  3. The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia

  • J Clin Invest. 2024 Jan 2;134(1):e171172. doi: 10.1172/JCI171172.
Garth T Whiteside 1,  Donald J Kyle 2,  Ram P Kapil 1,  Alessandra Cipriano 1,  Ellie He 1,  Mingyan Zhou 1,  Manjunath S Shet 1,  Michele Hummel 2,  Terri Knappenberger 2,  Kazuya Fukumura 3,  Yoshiyuki Matsuo 3,  Masahiro Uehira 3,  Shuichi Hiroyama 3,  Nozomi Takai 3,  Sandra K Willsie 4,  Stephen C Harris 1
Affiliations

Affiliations

  • 1 Imbrium Therapeutics, Stamford, Connecticut, USA.
  • 2 Purdue Pharma LP, Stamford, Connecticut, USA.
  • 3 Shionogi & Co. Ltd., Osaka, Japan.
  • 4 Pharmaceutical Research Associates, Raleigh, North Carolina, USA.
PMID: 37883189 DOI: 10.1172/JCI171172
Abstract

The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.

Keywords

Neuroscience; Pharmacology; Therapeutics.

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