2. Academic Validation
  3. Two new sesquiterpene glycosides from Dendrobium findleyanum

Two new sesquiterpene glycosides from Dendrobium findleyanum

  • Nat Prod Res. 2025 Jul;39(13):3751-3759. doi: 10.1080/14786419.2024.2313191.
Zhongquan Cheng 1,  Weiwei Fan 2,  Jiangmiao Hu 3,  Dan Yang 4
Affiliations

Affiliations

  • 1 College of Pharmacy, Guangzhou Health Science College, Guangzhou, P. R. China.
  • 2 Henan Engineering Research Center of Funiu Mountain's Medicinal Resources Utilization and Molecular Medicine, College of Medicine, Pingdingshan University, Pingdingshan, P. R. China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
  • 4 Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan, P. R. China.
PMID: 38329059 DOI: 10.1080/14786419.2024.2313191
Abstract

One new ylangene-type sesquiterpene glycoside, findlayanoside C (1), and one new picrotoxane-type sesquiterpene glycoside, findlayanoside D (3), together with five known sesquiterpene glycosides, dendrofindlayanoside C (2), dendronobiloside B (4), dendronobiloside A (5), dendroside F (6) and dendromoniliside D (7), have been isolated from the stems of Dendrobium findleyanum. The structures of compounds 1 and 3 were elucidated by means of extensive spectroscopic analyses, and their absolute configuration were confirmed by electronic circular dichroism (ECD) calculations. Cytotoxic activity assays against SMMC-7721, A-549 and MCF-7 human Cancer cell lines revealed IC50 values of 10.12, 12.32 and 14.13 μM for compound 1, and of 9.25, 13.16 and 16.26 μM for compound 2. This study enriches the anti-tumour sesquiterpenoids composition of D. findleyanum.

Keywords

Dendrobium findleyanum; antitumor activity; findlayanoside; sesquiterpene glycoside.

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