2. Academic Validation
  3. A role for RIO kinases in the crosshair of cancer research and therapy

A role for RIO kinases in the crosshair of cancer research and therapy

  • Biochim Biophys Acta Rev Cancer. 2024 May;1879(3):189100. doi: 10.1016/j.bbcan.2024.189100.
Morteza Ghandadi 1,  Albert Dobi 2,  Sanjay V Malhotra 3
Affiliations

Affiliations

  • 1 Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran; Medicinal Plants Research Center, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: Ghandadi@yahoo.com.
  • 2 Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery at the Uniformed Services, University of the Health Sciences, Bethesda, MD 20817, USA; Henry Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.
  • 3 Department of Cell, Development and Cancer Biology, Oregon Health & Science University, Portland, OR 97201, USA; Center for Experimental Therapeutics, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201, USA.
PMID: 38604268 DOI: 10.1016/j.bbcan.2024.189100
Abstract

RIO (right open reading frame) family of kinases including RIOK1, RIOK2 and RIOK3 are known for their role in the ribosomal biogenesis. Dysfunction of RIO kinases have been implicated in malignancies, including acute myeloid leukemia, glioma, breast, colorectal, lung and prostatic adenocarcinoma suggesting RIO kinases as potential targets in Cancer. In vitro, in vivo and clinical studies have demonstrated that RIO kinases are overexpressed in various types of cancers suggesting important roles in tumorigenesis, especially in metastasis. In the context of malignancies, RIO kinases are involved in cancer-promoting pathways including Akt/mTOR, Ras, p53 and NF-κB and cell cycle regulation. Here we review the role of RIO kinases in Cancer development emphasizing their potential as therapeutic target and encouraging further development and investigation of inhibitors in the context of Cancer.

Keywords

Cancer; Metastasis; Multidrug resistance; RIOK1; RIOK2; RIOK3.

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