2. Academic Validation
  3. Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures

Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures

  • Antimicrob Agents Chemother. 1994 Oct;38(10):2465-8. doi: 10.1128/AAC.38.10.2465.
P K Peterson 1,  G Gekker,  S Hu,  C C Chao
Affiliations

Affiliation

  • 1 Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415.
PMID: 7530933 DOI: 10.1128/AAC.38.10.2465
Abstract

Antiviral activities of the Reverse Transcriptase inhibitors U-90152 and 3'-azido-2',3'-dideoxythymidine and the protease inhibitor U-75875 were compared in two culture models of human immunodeficiency virus type 1 brain Infection. In a model involving acutely infected microglial cells, U-90152 was the most active, whereas in a model using chronically infected promonocytes, U-75875 was the most active.

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