2. Neuronal Signaling Metabolic Enzyme/Protease
  3. Monoamine Oxidase Drug Metabolite
  4. MDL 72392

MDL 72392 是一种选择性不可逆单胺氧化酶 A (MAO-A) 抑制剂。MDL 72392 抑制 MAO-A。MDL 72392 可由生物前体氨基酸 MDL 72394 经芳香族 L-氨基酸脱羧酶脱羧生成。MDL 72392 可用于褪黑素生物合成研究。

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MDL 72392

MDL 72392 Chemical Structure

CAS No. : 85278-68-8

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MDL 72392 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MDL 72392 is a selective irreversible monoamine oxidase A (MAO-A) inhibitor. MDL 72392 inhibits MAO-A. MDL 72392 is formed by decarboxylation of the bioprecursor amino acid MDL 72394 via aromatic L-amino acid decarboxylase. MDL 72392 can be used in melatonin biosynthesis research[1].

IC50 & Target[1]

MAO-A

 

体内研究
(In Vivo)
Animal Model: Fisher 344N (male, 2 months old, 200 g body weight)[1]
Dosage: Generated in vivo via decarboxylation of systemically administered MDL 72394 (0.5 mg/kg)
Administration: i.p.; single dose
Result: Elevated pineal melatonin levels to 1.49 ng/pineal.
Elevated pineal 5-HT levels to 52.96 ng/pineal.
Elevated pineal NAS levels to 1.4 ng/pineal.
Reduced pineal 5-HIAA levels to 2.15 ng/pineal relative to saline controls.
分子量

167.18

Formula

C9H10FNO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MDL 72392 相关分类

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Keywords:

MDL 7239285278-68-8MDL72392MDL-72392Monoamine OxidaseDrug MetaboliteMAON-acetylserotoninblood-brain barriermonoamine oxidase Arat pinealmelatonin biosynthesismelatonin5-hydroxyindole acetic acidpineal serotoninMAO-AInhibitorinhibitorinhibit

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