2. PI3K/Akt/mTOR Apoptosis Others
  3. Akt Bcl-2 Family Drug Derivative
  4. Mito-fisetin mF7

Mito-fisetin mF7 是 Fisetin (HY-N0182) 的一种亲脂性衍生物。Mito-fisetin mF7 可与 AKT 和 Bcl-2 相互作用，限制二者的稳定性与功能。Mito-fisetin mF7 会损伤线粒体功能并降低雌激素受体 (ER) 阳性癌细胞的代谢活性。Mito-fisetin mF7 可用于 ER 阳性乳腺癌的相关研究。

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Mito-fisetin mF7

Mito-fisetin mF7 Chemical Structure

CAS No. : 3106880-06-9

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Mito-fisetin mF7 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mito-fisetin mF7 is a lipophilic derivative of Fisetin (HY-N0182). Mito-fisetin mF7 interacts with AKT and Bcl-2, limiting their stability and functionality. Mito-fisetin mF7 stimulates impairs mitochondrial function and reduces metabolic activity of ER-positive cancer cells. Mito-fisetin mF7 can be used for the research of ER-positive breast cancer[1].

IC50 & Target[1]

Bcl-2

 

体外研究
(In Vitro)

Mito-fisetin mF7 (1-10 μM; 24 h) 可降低 ER 阳性 HCC1500、CAMA-1、HCC1428 及 ZR-75-30 乳腺癌细胞的代谢活性，而正常 BJ 成纤维细胞和 MCF10F 细胞的敏感性较低[1]。
Mito-fisetin mF7 (5 μM; 6 h) 可破坏增殖状态下 HCC1428 乳腺癌细胞的线粒体功能[1]。
Mito-fisetin mF7 (0.01-5 μM; 过夜) 可直接与重组人 AKT 和 Bcl-2 蛋白相互作用，通过点印迹密度测定法检测发现其可降低上述蛋白的可检测水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mito-fisetin mF7 相关抗体:

Cell Viability Assay[1]

Cell Line: normal BJ fibroblasts, noncancerous mammary epithelial MCF10F cells, ER-positive breast cancer cell lines (HCC1500, CAMA-1, HCC1428, ZR-75-30)
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Reduced metabolic activity in all tested ER-positive breast cancer cell lines, with effects more pronounced than unmodified Fisetin (HY-N0182) at all concentrations.
Showed less sensitivity in normal BJ fibroblasts and MCF10F cells compared to breast cancer cells.
分子量

936.76

Formula

C52H42IO7P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mito-fisetin mF7 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mito-fisetin mF73106880-06-9AktBcl-2 FamilyDrug DerivativePKBProtein kinase BDrug derivativeapoptosismitochondrial functionCAMA-1AKTHCC1500mitochondrial membrane potentialBcl-2oxidative stressmitophagic responseER-positive breast cancer cellsInhibitorinhibitorinhibit

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