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  4. MOR102

MOR102 是一种全人源 IgG4 单克隆抗体，同时也是 ICAM-1 抑制剂，与 ICAM-2 和 ICAM-3 无交叉反应。MOR102 结合 ICAM-1 结构域 1 内的 LFA-1 结合位点，阻断 ICAM-1/LFA-1 相互作用，可结合人角质形成细胞，且与干扰素-γ 刺激的角质形成细胞的结合力更强。MOR102 可抑制淋巴细胞黏附，减少淋巴细胞增殖，阻止局部 T 细胞活化，减轻炎性浸润，恢复正角化分化，并降低表皮厚度。MOR102 可用于银屑病的研究。

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MOR102

MOR102 Chemical Structure

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MOR102 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MOR102 is a fully human IgG4 monoclonal antibody and an ICAM-1 inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the LFA-1 binding site within ICAM-1 domain 1, blocks ICAM-1/LFA-1 interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis[1][2].

同型

Fab-G4-nd
反应种属

Human
体外研究
(In Vitro)

MOR102 (0.04-10 μg/mL; 30 min) 可强效抑制人 SKW-3 T 细胞白血病细胞与固定化重组 ICAM-1 的黏附作用，其 IC50 为 3 nM[1]。
MOR102 (0.5-50 μg/mL; 4 days) 可降低混合淋巴细胞培养体系中人外周血单个核细胞的增殖活性[1]。
MOR102 (10 μg/mL; overnight) 可结合人源 HaCaT 角质形成细胞，且在经 IFN-γ 刺激的 HaCaT 细胞上观察到结合增强的现象[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MOR102 相关抗体:
体内研究
(In Vivo)

MOR102 (10 mg/kg；腹腔注射；隔日一次；移植后第 22 至 50 天，持续 4 周) 可显著降低银屑病 SCID 小鼠模型的表皮厚度并减少炎性浸润[1]。
MOR102 (10 mg/kg；腹腔注射；隔日一次；持续 4 周) 可诱导正角化分化，降低表皮厚度，并减少 SCID 小鼠背部人慢性斑块状银屑病皮肤移植物中的炎性浸润[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C.B17 SCID mice (6-8 weeks old) transplanted with human split skin grafts[1]
Dosage: 10 mg/kg
Administration: i.p.; every alternate day; 4 weeks from day 22-50 after transplantation
Result: Reduced mean epidermal thickness to 255 μm, a significant reduction compared to control.
Reduced mean inflammatory infiltrate density to 136 cells per high-power field, a marked reduction compared to PBS-treated controls.
Induced reconstitution of orthokeratotic differentiation of the epidermis, with moderate acanthosis, mild papillomatosis, a web-like corneal layer with mild remaining parakeratosis, and a re-established granular layer.
Demonstrated intense staining of keratinocytes in grafts via immunohistochemistry, confirming targeting of ICAM-1 on keratinocytes.
Animal Model: SCID mice transplanted with human split skin grafts[2]
Dosage: 10 mg/kg
Administration: i.p.; every other day; 4 weeks
Result: Reconstituted orthokeratotic differentiation of the transplanted skin.
Significantly reduced epidermal thickness.
Markedly reduced the inflammatory infiltrate within the graft.
基因 ID

3383  [NCBI]

Accession
靶点

ICAM1/CD54
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MOR102 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOR102MOR 102MOR-102IntegrinECV304 bladder carcinoma cellshuman keratinocyteshuman peripheral blood mononuclear cellsinterferon-γHaCaT keratinocytesLFA-1psoriasis-SCID mouse modelchronic plaque-stage psoriasisICAM-1SKW-3 T-cell leukaemia cellsInhibitorinhibitorinhibit

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