2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme Heme Oxygenase (HO)
  4. N,N-dimethyldithiocarbamate potassium

N,N-dimethyldithiocarbamate potassium 是一种泛素激活酶 E1 抑制剂。N,N-dimethyldithiocarbamate potassium 可抑制 E1 的激活，降低活化的泛素化 E1 (ub-E1) 水平。N,N-dimethyldithiocarbamate potassium 可提高细胞内铜水平，增强氧化应激，提升蛋白质羰基水平，上调 HO-1 的表达。N,N-dimethyldithiocarbamate potassium 可用于帕金森病的相关研究。

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N,N-dimethyldithiocarbamate potassium

N,N-dimethyldithiocarbamate potassium Chemical Structure

CAS No. : 128-03-0

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N,N-dimethyldithiocarbamate potassium 相关抗体

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查看 Heme Oxygenase (HO) 亚型特异性产品:

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HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N,N-dimethyldithiocarbamate potassium is a ubiquitin-activating enzyme E1 inhibitor. N,N-dimethyldithiocarbamate potassium inhibits the activation of E1 and reduces the level of activated ubiquitinated E1 (ub-E1). N,N-dimethyldithiocarbamate potassium increases intracellular copper levels, enhances oxidative stress, elevates protein carbonyl levels, and upregulates the expression of HO-1[1]. N,N-dimethyldithiocarbamate potassium is applicable to research related to Parkinson's disease[1].

IC50 & Target[1]

HO-1

 

体外研究
(In Vitro)

N,N-dimethyldithiocarbamate (20 μM; 6 h) potassium 可抑制 HEK293 细胞中泛素激活酶 E1 的激活，使 ub-E1/E1 比值相对于对照组降至 0.25[1]。
N,N-dimethyldithiocarbamate (20 μM; 6 h) potassium 可显著上调 HEK293 细胞中血红素氧合酶-1 蛋白的表达，该蛋白是氧化应激的标志物[1]。
N,N-dimethyldithiocarbamate (20 μM; 6 h) potassium 可显著升高 HEK293 细胞内的铜水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N,N-dimethyldithiocarbamate potassium 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 20 μM
Incubation Time: 6 h
Result: Significantly decreased the ub-E1/E1 ratio to 0.25 relative to control (p < 0.01, n = 5).
Detected no dithiocarbamate-derived E1 adducts (S-methylaminocarbonyl or glutathiotinylation) in E1-enriched cell extracts via LC/MS/MS. Significantly increased protein carbonyl levels relative to control (p < 0.05, n = 5). Significantly increased HO-1 protein expression relative to control (p < 0.01, n = 5).
分子量

159.31

Formula

C3H6KNS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N,N-dimethyldithiocarbamate potassium 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

N,N-dimethyldithiocarbamate128-03-0E1/E2/E3 EnzymeHeme Oxygenase (HO)E1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseHeme Oxygenaselipid peroxidationHEK293 cellsintracellular copperprotein carbonylheme oxygenase-1oxidative stressubiquitin activating enzyme E1parkinson’s diseaseubiquitinated E1Inhibitorinhibitorinhibit

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