2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism Drug Metabolite
  4. N-Oleoyl-L-phenylalanine

N-Oleoyl-L-phenylalanine 是一种长链 N-酰基-L-苯丙氨酸，同时也是一种线粒体解偶联剂 (mitochondrial uncoupler)。N-Oleoyl-L-phenylalanine 能使线粒体中不依赖解偶联蛋白 UCP1 的呼吸作用解偶联，从而有助于调节葡萄糖稳态。N-Oleoyl-L-phenylalanine 作为一种体内代谢物，其水平在高脂饮食后的溃疡性结肠炎患者体内会升高。N-Oleoyl-L-phenylalanine 可用于溃疡性结肠炎的相关研究。

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Custom Peptide Synthesis

N-Oleoyl-L-phenylalanine

N-Oleoyl-L-phenylalanine Chemical Structure

CAS No. : 136560-78-6

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规格 价格 是否有货 数量
1 mg (23.28 mM * 100 μL in Ethanol) ￥540
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N-Oleoyl-L-phenylalanine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Oleoyl-L-phenylalanine is a long-chain N-acyl-L-phenylalanine and also a mitochondrial uncoupler. N-Oleoyl-L-phenylalanine uncouples UCP1-independent respiration in mitochondria, thereby helping to regulate glucose homeostasis. As an endogenous metabolite, the level of N-Oleoyl-L-phenylalanine increases in patients with ulcerative colitis after a high-fat diet. N-Oleoyl-L-phenylalanine can be used in studies related to ulcerative colitis[1][2].

体外研究
(In Vitro)

N-oleoyl-L-phenylalanine 可解偶联哺乳动物线粒体中不依赖 UPC1 的呼吸作用，且可能参与葡萄糖稳态的调控[2]。
N-oleoyl-L-phenylalanine 属于内源性细胞信号类脂质分子，与内大麻素类脂质结构相关[2]。
N-oleoyl-L-phenylalanine 可由哺乳动物酶肽酶 M20 结构域 PM20D1 在生理 pH 与底物浓度条件下，通过催化油酸与 L-苯丙氨酸直接缩合生成，其生成量符合细胞内 L-苯丙氨酸、油酸浓度与反应平衡常数 (Keq) 的对应关系[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Oleoyl-L-phenylalanine 相关抗体:
体内研究
(In Vivo)

N-oleoyl-L-phenylalanine 属于 N-酰基芳香族氨基酸 (NA-ArAAs)，是一种长链脂化氨基酸，已在小鼠大脑等生物样本中被检测并定量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

429.64

Formula

C27H43NO3
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: 99.4%

COA (256 KB)

产品使用指南 (1538 KB)
参考文献

N-Oleoyl-L-phenylalanine 相关分类

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Keywords:

N-Oleoyl-L-phenylalanine136560-78-6Mitochondrial MetabolismDrug Metabolitemitochondriaulcerative colitis patientsglucose homeostasismammalian mitochondriauncoupling protein 1mitochondrial uncouplerhigh fat dietInhibitorinhibitorinhibit

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