2. Anti-infection Membrane Transporter/Ion Channel
  3. Bacterial ATP Synthase
  4. ND-011458

ND-011458 是抗菌 (Antibacterial) 剂、 QcrB 抑制剂，同时也是细胞色素 bcc:aa3 氧化酶功能抑制剂。ND-011458 可结合细胞色素 bcc:aa3 氧化酶的 QcrB 亚基。ND-011458 抑制 ATP 形成。ND-011458 当与 Clofazimine (HY-B1046) 联用时，对脓肿分枝杆菌具有杀菌活性。ND-011458 可用于脓肿分枝杆菌肺部感染的相关研究。

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ND-011458

ND-011458 Chemical Structure

CAS No. : 1648720-01-7

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ND-011458 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ND-011458 is an Antibacterial agent, a QcrB inhibitor, and also an inhibitor of cytochrome bcc:aa3 oxidase function. ND-011458 binds to the QcrB subunit of cytochrome bcc:aa3 oxidase. ND-011458 inhibits ATP formation. When used in combination with Clofazimine (HY-B1046), ND-011458 exhibits bactericidal activity against *Mycobacterium abscessus*. ND-011458 can be used in studies related to *Mycobacterium abscessus* pulmonary infections[1].

体外研究
(In Vitro)

ND-011458 可强效抑制脓肿分枝杆菌复合群多个亚种的生长并消耗其细胞内 ATP[1]。
ND-011458 可直接抑制纯化重组脓肿分枝杆菌 cyt-bcc:aa3 氧化酶的呼吸作用，证实其靶向该酶复合物[1]。
ND-011458 (0.1-20 μM; 3 days, checkerboard assay) 与 Clofazimine 具有相加作用，可抑制脓肿分枝杆菌的生长 (FIC index = 0.82)；二者联合 (10 μM ND-011458 + 8 μM CFZ) 具有杀菌活性，可在 4 天内使细菌载量降低约 1 log[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ND-011458 相关抗体:
分子量

542.98

Formula

C28H26ClF3N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ND-011458 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ND-0114581648720-01-7ND011458ND 011458BacterialATP Synthasemycobacterium abscessus pulmonary infectionsQN-binding pocketM. abscessus subsp. abscessus S morphotypeMycobacterium abscessus complexM. abscessus subsp. abscessus R morphotypeClofazimineQcrAcytochrome bcc:aa3 oxidaseMycobacterium abscessusQcrBInhibitorinhibitorinhibit

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