2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. NH4-6

NH4-6 是一种 SIRT2 抑制剂，对 SIRT2 的 IC50 为 0.032 μM，对 SIRT1 的 IC50 为 3 μM。NH4-6 可抑制 SIRT1 的脱乙酰酶活性。NH4-6 可作为细胞毒剂，降低癌细胞活力，抑制癌细胞的锚定非依赖性生长，诱导 α-微管蛋白 (α-tubulin) 乙酰化，并诱导 p53 乙酰化。NH4-6 可用于乳腺癌的研究。

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NH4-6

NH4-6 Chemical Structure

CAS No. : 2375182-58-2

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NH4-6 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NH4-6 is a SIRT2 inhibitor with an IC50 of 0.032 μM against SIRT2 and an IC50 of 3 μM against SIRT1. NH4-6 inhibits the deacetylase activity of SIRT1. As a cytotoxic agent, NH4-6 reduces cancer cell viability, suppresses anchorage-independent growth of cancer cells, induces acetylation of α-tubulin, and promotes acetylation of p53. NH4-6 can be used in the research of breast cancer[1].

IC50 & Target[1]

SIRT2

0.032 μM (IC50)

SIRT1

3 μM (IC50)

体外研究
(In Vitro)

NH4-6 可强效且选择性地抑制纯化的 SIRT2 脱乙酰酶活性，其 IC50 为 0.032 μM；对 SIRT1 和 SIRT6 的活性抑制作用较弱，且在 83 μM 条件下不抑制 SIRT3[1]。
NH4-6 (25-50 μM; 6 h) 在 MCF7 和 MDA-MB-231 乳腺癌细胞中表现出细胞毒性[1]。
NH4-6 (12 μM; 10 days) 在 MCF7 乳腺癌细胞中抑制锚定非依赖性生长[1]。
NH4-6 (25-100 μM; 6 h) 上调 MCF7 乳腺癌细胞中 α-微管蛋白的乙酰化水平 (SIRT2 抑制的标志物)[1]。
NH4-6 (10-100 μM) 仅在 100 μM 浓度下抑制 MCF7 乳腺癌细胞中的 SIRT1 活性 (通过 p53 乙酰化水平检测)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NH4-6 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF7, MDA-MB-231 breast cancer cells
Concentration: 25 μM, 50 μM
Incubation Time: 6 h
Result: Showed slightly weaker cytotoxicity than TM in both MCF7 and MDA-MB-231 cells at lower concentrations.
Showed stronger cytotoxicity than TM in both cell lines at 50 μM.
Reached intracellular levels of 0.19 μg/million cells after 25 μM treatment and 0.86 μg/million cells after 50 μM treatment, compared to saturated levels of TM (~0.29-0.30 μg/million cells) at both concentrations.

Immunofluorescence[1]

Cell Line: MCF7 breast cancer cells
Concentration: 25 μM; 50 μM; 100 μM
Incubation Time: 6 h
Result: Did not increase α-tubulin acetylation levels at 25 μM.
Increased α-tubulin acetylation levels to levels comparable to TM-treated samples at 50 μM and 100 μM.
分子量

718.82

Formula

C33H59IN4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NH4-6 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH4-62375182-58-2SirtuinSIRT3MDA-MB-231 cellsMCF7 cellsbreast cancerSIRT1SIRT2SIRT6p53α-tubulinInhibitorinhibitorinhibit

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