2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. NP-184

NP-184 是一种新型口服活性抗血栓剂。NP-184 选择性抑制 TXA2 合成酶活性，其 IC50 值为 4.3 μM。NP-184 具有抗血小板和抗血栓活性。NP-184 可用于血栓栓塞性疾病的研究。

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NP-184

NP-184 Chemical Structure

CAS No. : 78706-11-3

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NP-184 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NP-184 is a novel orally active antithrombotic agent. NP-184 selectively inhibits TXA2 synthase activity with an IC50 value of 4.3 μM. NP-184 has antiplatelet and antithrombotic activities. NP-184 can be used in the research of thromboembolic diseases[1].

IC50 & Target

IC50: 4.3 μM (TXA2 synthase)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
102.54 μM
Compound: 4b
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 28505536]
MCF7 IC50
14 μg/mL
Compound: 3b
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay
[PMID: 24576797]
MCF7 IC50
55.55 μM
Compound: 4b
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay
[PMID: 28505536]
分子量

198.22

Formula

C12H10N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NP-184 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NP-18478706-11-3NP184NP 184Prostaglandin ReceptorMiceantiplateletantithromboticInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-W169940
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