2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. NSC 620023 TFA

NSC 620023 TFA 是一种高选择性丁酰胆碱酯酶 (BChE) 抑制剂，其 IC50 为 32 nM。NSC 620023 TFA 通过与双苯并咪唑结构域的 π-堆积作用以及在 BChE 结合位点内的疏水相互作用发挥功能。NSC 620023 TFA 可用于阿尔茨海默病的研究。

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NSC 620023 TFA

NSC 620023 TFA Chemical Structure

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NSC 620023 TFA 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC 620023 TFA is a highly selective butyrylcholinesterase (BChE) inhibitor with an IC50 of 32 nM. NSC 620023 TFA acts via π-stacking interactions with dual benzimidazole moieties and hydrophobic interactions within the BChE binding site. NSC 620023 TFA can be used for the research of alzheimer’s disease[1].

IC50 & Target[1]

hBCHE

32 nM (IC50)

hAChE

>>5000 nM (IC50)

体外研究
(In Vitro)

NSC 620023 (5 μM; 10-30 min) TFA 可强效且选择性地抑制纯化的人丁酰胆碱酯酶，其 IC50 为 32 nM，且在浓度高达 5 μM 时对乙酰胆碱酯酶无抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 620023 TFA 相关抗体:
分子量

716.71

Formula

C31H30F6N4O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC 620023 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 620023NSC620023NSC-620023Cholinesterase (ChE)BChEbenzimidazole moietieshuman butyrylcholinesterasealzheimer’s diseasebutyrylcholinesteraseBChE binding siteacetylcholinesteraseInhibitorinhibitorinhibit

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