2. GPCR/G Protein MAPK/ERK Pathway PI3K/Akt/mTOR Stem Cell/Wnt Protein Tyrosine Kinase/RTK
  3. Ras Akt ERK VEGFR
  4. NY0123

NY0123 是一种 EPAC1 抑制剂。NY0123 显著抑制 EPAC1、磷酸化 AKT、磷酸化 ERK1/2 和磷酸化 VEGFR2 的表达。NY0123 可抑制三阴性乳腺癌的血管生成与肿瘤生长。NY0123 可用于三阴性乳腺癌的相关研究。

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NY0123

NY0123 Chemical Structure

CAS No. : 1801911-70-5

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NY0123 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NY0123 is a EPAC1 inhibitor. NY0123 significantly inhibits the expression of EPAC1, phosphorylated AKT, phosphorylated ERK1/2 and phosphorylated VEGFR2. NY0123 inhibits angiogenesis and tumor growth of triple-negative breast cancer. NY0123 is applicable to relevant research on triple-negative breast cancer[1].

IC50 & Target[1]

VEGFR2

 

ERK1

 

ERK2

 

EPAC1

 

体内研究
(In Vivo)

NY0123 (10 mg/kg；腹腔注射；每 2 天 1 次) 可显著抑制 BALB/c 小鼠体内三阴性乳腺癌的肿瘤生长、血管生成及细胞增殖，其疗效优于 ESI-09，且未观察到器官毒性[1]。
NY0123 (25-100 μM；鸡胚尿囊膜局部给予；单次；孵育 48 h) 可显著抑制 Gallus gallus domesticus (家鸡) 胚胎尿囊膜模型中的血管生成，且效果优于 ESI-09[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 5-6 weeks old, 4T1 cell xenograft model)[1]
Dosage: 10 mg/kg
Administration: i.p.; every two days; 14 days
Result: Significantly reduced tumor volume and tumor weight compared to DMSO control.
Significantly lowered tumor microvessel density (measured via CD31 IHC staining) and tumor cell proliferation index (measured via Ki67 IHC staining) compared to DMSO control.
Exhibited greater inhibitory effects on tumor volume, tumor weight, MVD, and proliferation index than ESI-09.
Showed no treatment-related organ toxicities via H&E staining of heart, liver, lung, brain, spleen, kidney, and intestine tissues.
Animal Model: White leghorn (7-day-old embryo, CAM vascularization model)[1]
Dosage: 25 μM, 50 μM, 100 μM
Administration: topical application to CAM; single dose; 48-hour incubation
Result: Significantly reduced CAM microvessel density at 100 μM compared to DMSO control.
Exhibited greater inhibitory effects on angiogenesis at 100 μM than ESI-09 at the same concentration.
分子量

399.66

Formula

C16H13Cl3N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NY0123 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NY01231801911-70-5NY 0123NY-0123RasAktERKVEGFRPKBProtein kinase BExtracellular signal regulated kinasesVascular endothelial growth factor receptorangiogenic signaling networksPI3K/AKT pathwaysMEK/ERK pathwaysVEGF/VEGFR2 signalingtriple-negative breast cancervascular endothelial cellsBALB/c miceEPAC1Notch pathwaychick embryo CAM xenograft modelsInhibitorinhibitorinhibit

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