2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Folate Receptor (FR)
  4. Opugotamig olatansine

Opugotamig olatansine (IMGN151) 是一种靶向叶酸受体 α (FRα) 的抗体药物偶联物 (ADC)。Opugotamig olatansine 由抗体 Opugotamig (HY-P990935) 和连接子-载荷 NMS-P945 (HY-185569) 组成。Opugotamig olatansine 可结合 FRα 的两个独立表位，促进抗体的结合、内化及加工过程。Opugotamig olatansine 可用于 FRα 阳性卵巢癌的相关研究。

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Opugotamig olatansine

Opugotamig olatansine Chemical Structure

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Opugotamig olatansine 相关抗体

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查看 Folate Receptor (FR) 亚型特异性产品:

查看所有亚型
FR-α

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Opugotamig olatansine (IMGN151) is a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC). Opugotamig olatansine comprises antibody Opugotamig (HY-P990935) and linker-payload NMS-P945 (HY-185569). Opugotamig olatansine binds to two independent epitopes of FRα and promotes antibody binding, internalization, and processing. Opugotamig olatansine can be used for the research of FRα-positive ovarian cancer[1].

体外研究
(In Vitro)

Opugotamig olatansine 相比亲本单特异性抗体，可使 JHOS4 中表达 FRα 的肿瘤细胞的抗体结合事件及加工过程提升 100%，使高表达 FRα 的 KB 肿瘤细胞的上述指标提升 170%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Opugotamig olatansine 相关抗体:
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Opugotamig olatansine 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opugotamig olatansineIMGN-151IMGN151IMGN 151Antibody-Drug Conjugates (ADCs)Folate Receptor (FR)Antibody-Drug ConjugatesKBtumor cellsFRαJHOS4antibody-drug conjugate internalizationovarian cancer modelsFolate Receptor alphacynomolgus monkey modelsInhibitorinhibitorinhibit

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