2. PI3K/Akt/mTOR JAK/STAT Signaling Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Akt mTOR JAK STAT Apoptosis Caspase Reactive Oxygen Species (ROS) NO Synthase
  4. PI3K/Akt/mTOR-IN-7

PI3K/Akt/mTOR-IN-7 是一种 AKT/mTOR 和 JAK2/STAT3 抑制剂。PI3K/Akt/mTOR-IN-7 可恢复 p-Akt、p-mTOR 和 p-STAT3 的表达水平，并降低促凋亡蛋白 Caspase-3 mRNA 的表达。PI3K/Akt/mTOR-IN-7 可减少细胞内 ROS 的积累，并抑制 NO 的生成。PI3K/Akt/mTOR-IN-7 可用于中风、阿尔茨海默病和帕金森病的研究。

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PI3K/Akt/mTOR-IN-7

PI3K/Akt/mTOR-IN-7 Chemical Structure

CAS No. : 2925588-01-6

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PI3K/Akt/mTOR-IN-7 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/Akt/mTOR-IN-7 is an AKT/mTOR and JAK2/STAT3 inhibitor. PI3K/Akt/mTOR-IN-7 restores p-Akt, p-mTOR, and p-STAT3 expression, reduces pro-apoptotic Caspase-3 mRNA expression. PI3K/Akt/mTOR-IN-7 reduces intracellular ROS accumulation and inhibits NO production. PI3K/Akt/mTOR-IN-7 can be used for research on stroke, Alzheimer's disease and Parkinson's disease[1].

IC50 & Target[1]

JAK2

 

STAT3

 

Caspase-3

 

体外研究
(In Vitro)

PI3K/Akt/mTOR-IN-7 (DG23) (10 μM；24 小时) 对 BV2 小胶质细胞无显著细胞毒性[1]。
PI3K/Akt/mTOR-IN-7 (10 μM；24 小时) 可在 10 μM 浓度下使 LPS (HY-D1056) 刺激的 BV2 小胶质细胞中一氧化氮的生成量抑制 51.62%[1]。
PI3K/Akt/mTOR-IN-7 (10 μM；24 小时) 对人神经母细胞瘤 SH-SY5Y 细胞在 10 μM 浓度下无明显细胞毒性[1]。
PI3K/Akt/mTOR-IN-7 (10 μM；26 小时) 可在 SH-SY5Y 人神经母细胞瘤细胞中发挥神经保护作用，抵御 H2O2 诱导的氧化损伤；其在 10 μM 浓度下的细胞存活率挽救率为 42.68%，且呈现浓度依赖性的保护效应[1]。
PI3K/Akt/mTOR-IN-7 (10 μM；8 小时) 对 SH-SY5Y 人神经母细胞瘤细胞中 H2O2 诱导的促凋亡 Bcl-2/Bax 和 Caspase-3 mRNA 表达上调具有强效抑制作用[1]。
PI3K/Akt/mTOR-IN-7 (2.5-10 μM；8 小时) 可剂量依赖性地抑制 H2O2 诱导的人神经母细胞瘤 SH-SY5Y 细胞中活性氧的积累，在 5 μM 和 10 μM 浓度下可观察到显著效应[1]。
PI3K/Akt/mTOR-IN-7 (2.5-10 μM；8 小时) 可呈剂量依赖性降低 H2O2 诱导的 Caspase-3 蛋白表达，并在 2.5-10 μM 浓度下恢复人神经母细胞瘤 SH-SY5Y 细胞中 p-Akt、p-mTOR 和 p-STAT3 的蛋白表达，其效力高于薯蓣皂苷元[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/Akt/mTOR-IN-7 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: BV2 microglial cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Showed no significant cytotoxicity in BV2 cells.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Showed no obvious cytotoxicity in SH-SY5Y cells.

Real Time qPCR[1]

Cell Line: H2O2-injured SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: 26 h
Result: Significantly attenuated H2O2-induced upregulation of Bcl-2/Bax and Caspase-3 mRNA expression.
Reduced the Bcl-2/Bax ratio to 3.54 and Caspase-3 expression to 1.03.

Western Blot Analysis[1]

Cell Line: H2O2-injured SH-SY5Y human neuroblastoma cells
Concentration: 2.5 μM; 5 μM; 10 μM
Incubation Time: 8 h
Result: Dose-dependently decreased H2O2-induced Caspase-3 protein expression, with marked downregulation in the 10 μM group relative to the H2O2-only group.
Dose-dependently upregulated the p-Akt/Akt, p-mTOR/mTOR, and p-STAT3/STAT3 ratios, restoring phosphorylated protein expression to levels superior to diosgenin at equivalent concentrations.
分子量

605.76

Formula

C36H47NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/Akt/mTOR-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/Akt/mTOR-IN-72925588-01-6AktmTORJAKSTATApoptosisCaspaseReactive Oxygen Species (ROS)NO SynthasePKBProtein kinase BMammalian target of RapamycinJanus kinaseNitric oxide synthasesNOSAKT/mTOR signaling pathwaysCaspase-3JAK2/STAT3 signaling pathwaysSH-SY5Y human neuroblastoma cellsreactive oxygen speciesnitric oxideSTAT3BV2 microglial cellsInhibitorinhibitorinhibit

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