2. Others Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis
  3. Reference Standards DNA-PK PI3K Apoptosis
  4. PIK-75 (Standard)

PIK-75 (Standard) 是 PIK-75 (HY-107834) 的分析标准品。本产品用于研究及分析应用。PIK-75 是一种可逆的 DNA-PK 和 p110α-选择性的抑制剂，抑制 DNA-PK，p110α 和 p110γ，IC50 分别为 2，5.8 和 76 nM。PIK-75 抑制 p110α 效果比抑制 p110β (IC50=1.3 μM) 高 200 多倍。PIK-75 诱导凋亡 (apoptosis)。

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PIK-75 (Standard)

PIK-75 (Standard) Chemical Structure

CAS No. : 372196-67-3

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PIK-75 (Standard) 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PIK-75 (Standard) is the analytical standard of PIK-75 (HY-107834). This product is intended for research and analytical applications. PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM)[1][2]. PIK-75 induces apoptosis[3].

IC50 & Target

IC50: 2 nM (DNA-PK), 5.8 nM (p110α), 76 nM (p110γ), 510 nM (p110δ), ~1 μM (PI3KC2β), ~1 μM (mTORC1), 1.3 μM (p110β), 2.3 μM (ATM), 2.6 μM (hsVPS34), ~10 μM (PI3KC2α), ~10 μM (mTORC2), ~50 μM (PI4KIIIβ), 21 μM (ATR)[1]
分子量

452.28

Formula

C16H14BrN5O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PIK-75 (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIK-75 (Standard)372196-67-3Reference StandardsDNA-PKPI3KApoptosisDNA-dependent protein kinasePhosphoinositide 3-kinasep110αPKBCHO-IRcellspancreaticcancerapoptoticInhibitorinhibitorinhibit

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