2. Immunology/Inflammation
  3. PSMA
  4. PSMA-SulfoCy7

PSMA-SulfoCy7 是一种靶向 PSMA/GCPII 的高亲和力显像剂 (对人 PSMA Ki=18.1 nM)。PSMA-SulfoCy7 能够调控 PSMA 依赖的 NAAG 水解作用。PSMA-SulfoCy7 具备优异的体内成像能力，可在异种移植物模型中对表达 PSMA 的肿瘤进行清晰的可视化成像，即使剂量为 87.9 mg/kg 时也无明确的毒性。PSMA-SulfoCy7 被广泛应用于前列腺癌的相关研究中。

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PSMA-SulfoCy7

PSMA-SulfoCy7 Chemical Structure

CAS No. : 2766510-90-9

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PSMA-SulfoCy7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSMA-SulfoCy7 is a high-affinity imaging agent targeting PSMA/GCPII (with a Ki of 18.1 nM for human PSMA). PSMA-SulfoCy7 regulates PSMA-dependent NAAG hydrolysis. PSMA-SulfoCy7 exhibits excellent in vivo imaging capability, enabling clear visualization of PSMA-expressing tumors in xenograft models, with no obvious toxicity even at a dose of 87.9 mg/kg. PSMA-SulfoCy7 is widely used in prostate cancer-related studies[1].

体外研究
(In Vitro)

PSMA-SulfoCy7 (2 h; 60 min) 可抑制 LNCaP 细胞裂解物中 PSMA 依赖的 NAAG 水解，其 Ki 值为 18 nM[1]。
PSMA-SulfoCy7 对 LNCaP 和 PC-3 前列腺癌细胞系具有细胞毒性，其 CC50 值分别为 12 μM 和 19 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSMA-SulfoCy7 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: LNCaP and PC-3 prostate cancer cell lines
Concentration: CC50
Incubation Time: /
Result: Inhibited LNCaP and PC-3 prostate cancer cell lines with CC50 values of 12 μM and 19 μM, respectively.
体内研究
(In Vivo)

PSMA-SulfoCy7 (250 nmol/kg；静脉注射；单次) 可在 PSMA 阳性 22Rv1 前列腺癌异种移植物中特异性聚集，在单次静脉注射 250 nmol/kg 后 24 小时，其体内荧光信号比 PSMA 阴性 PC-3 异种移植物高 2 倍[1]。
PSMA-SulfoCy7 (静脉注射；单次给药) 在兔和大鼠体内表现出血浆双相消除特征，消除半衰期分别为 1.39 h 和 1.78 h，主要分布于组织并经泌尿系统排泄[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice with Prostate cancer (male, 6-8 week-old, prostate cancer xenograft model)[1]
Dosage: 250 nmol/kg
Administration: i.v.; single dose
Result: Showed no reliable difference in tumor uptake between 22Rv1 and PC-3 xenografts at 0.5, 1, and 8 h post-injection.
Demonstrated a twofold higher fluorescence signal in 22Rv1 tumors compared to PC-3 tumors at 24 h post-injection.
Showed a significant difference in fluorescence signal between 22Rv1 and PC-3 tumors via ex vivo imaging at 24 h post-injection, with clearer distinction against background tissues.
分子量

1795.51

Formula

C90H112ClN13O20S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSMA-SulfoCy7 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-SulfoCy72766510-90-9PSMAProstate-specific membrane antigenxenograftsmiceprostate cancerGCPIILNCaP cell lysatePC-322Rv1NAAGLNCaPInhibitorinhibitorinhibit

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