2. GPCR/G Protein Neuronal Signaling Others
  3. 5-HT Receptor Drug Derivative
  4. R-MDDMA

R-MDDMA，一种亚甲二氧基甲基苯丙胺 (MDMA) 类似物，是 5-HT2A/5-HT2C 受体调节剂。R-MDDMA 对 5-HT2A/5-HT2C 具有拮抗活性，其 IC50 值分别为 642 和 137 nM，同时还具有部分激动剂活性，EC50 值分别为 24.5 和 14.4 nM，但不会激活 5-HT2B 受体。R-MDDMA 可促进皮质神经元生长。R-MDDMA 可促进恐惧消退学习，并在临床前啮齿动物模型中产生类抗抑郁作用。R-MDDMA 可用于创伤后应激障碍和抑郁症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

R-MDDMA

R-MDDMA Chemical Structure

CAS No. : 872679-98-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of R-MDDMA:

R-MDDMA 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R-MDDMA, 4-methylenedioxymethamphetamine (MDMA) analogue, is a 5-HT2A/5-HT2C receptor modulator. R-MDDMA shows antagonistic activity against 5-HT2A/5-HT2C with IC50 values of 642 and 137 nM, and also shows partial agonist activity with EC50 values of 24.5 and 14.4 nM, but does not activate 5-HT2B receptors. R-MDDMA promotes cortical neuron growth. R-MDDMA facilitates fear extinction learning and produces antidepressant-like effects in preclinical rodent models. R-MDDMA can be used for the researches of post-traumatic stress disorder and depression[1].

IC50 & Target[1]

5-HT2C Receptor

137 nM (IC50)

5-HT2A Receptor

642 nM (IC50)

5-HT2C Receptor

14.4 nM (EC50)

5-HT2A Receptor

24.5 nM (EC50)

体外研究
(In Vitro)

R-MDDMA (10 pM-10 μM; 24-72 h) 可强效通过 5-HT2 受体依赖机制促进 E18 胚胎大鼠皮层神经元的生长[1]。
R-MDDMA (100 μM; 15 min) 不会诱导表达 SERT 的 HEK293T 细胞发生血清素外流[1]。
R-MDDMA (10 pM-100 μM; 5 min) 在表达 psychLight2 生物传感器的 HEK293T 细胞中作为中等效力的 5-HT2A 受体拮抗剂，其 IC50 为 642 nM[1]。
R-MDDMA (10 pM-100 μM; 5 min) 在表达 GRAB5-HT 生物传感器的 HEK293T 细胞中作为 5-HT2C 受体的强效拮抗剂，其 IC50 为 137 nM[1]。
R-MDDMA (1 pM-1000 μM; 5 min) 是 5-HT2A 和 5-HT2C 受体的部分激动剂 (EC50 = 24.5 nM 和 14.4 nM)，但在 HEK293T 细胞中不会激活 5-HT2B 受体[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

R-MDDMA 相关抗体:

Cell Proliferation Assay[1]

Cell Line: cortical neurons
Concentration: 10 pM, 1, 100 nM, 10 μM
Incubation Time: 24, 72 h
Result: Promoted cortical neuron growth.
体内研究
(In Vivo)

R-MDDMA (12.5-50 mg/kg；腹腔注射；单次给药) 在治疗相关剂量 (12.5 mg/kg, 25 mg/kg) 下不会诱导体温过高、运动过度或甩头反应，但 50 mg/kg 剂量会引起短暂性体温过低、运动减少及趋触性增加[1]。
R-MDDMA (12.5-25 mg/kg；腹腔注射；单次给药；消退训练前 30 min) 在小鼠线索性恐惧条件化模型中，可促进持续性恐惧消退学习[1]。
R-MDDMA (12.5-25 mg/kg；腹腔注射；单次给药) 在小鼠悬尾实验中产生持续的类抗抑郁作用[1]。
R-MDDMA (12.5-25 mg/kg；腹腔注射；单次给药) 对小鼠三室社交互动实验或社交条件性位置偏爱实验未产生具有统计学意义的亲社会效应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (9−13 weeks old, mixed male and female)[1]
Dosage: 12.5 mg/kg; 25 mg/kg; 50 mg/kg
Administration: i.p.; single dose
Result: Did not produce statistically significant changes in locomotion or thigmotaxis at 12.5 mg/kg and 25 mg/kg.
Decreased locomotion and increased thigmotaxis at 50 mg/kg.
Did not induce head-twitch response at any dose.
Caused transient decrease in body temperature at 30 min post-administration with 50 mg/kg dose, which resolved within 30 min.
Did not detect body temperature changes with 12.5 mg/kg or 25 mg/kg doses over 2 hours.
Animal Model: Depressant C57BL/6J (9-13 weeks old, mixed male and female)[1]
Dosage: 12.5 mg/kg; 25 mg/kg
Administration: i.p.; single dose
Result: Did not reduce immobility time in the tail suspension test at 12.5 mg/kg dose.
Reduced immobility time to a comparable extent as positive control ketamine (3 mg/kg) at 25 mg/kg dose.
Completely blocked antidepressant-like effect of 25 mg/kg dose by pretreatment with 5-HT2 antagonist Ketanserin (HY-10562).
分子量

206.28

Formula

C13H18O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R-MDDMA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-MDDMA872679-98-65-HT ReceptorDrug DerivativeSerotonin Receptor5-hydroxytryptamine ReceptorDrug derivative5-HT2C receptorcortical neuronsmouse cued fear conditioning modelpreclinical rodent models5-HT2A receptorpost-traumatic stress disorderdepression5-HT2B receptorGq signalingHEK293T cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
R-MDDMA
目录号：
HY-186169
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z