R419

目录号: HY-153156 一键复制产品信息: Data Sheet 产品使用指南
FAQs
技术支持

R419 是一种复合物 I 抑制剂。R419 对肝癌具有抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

R419 Chemical Structure

CAS No. : 1356629-00-9

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格		是否有货
50 mg		询价
100 mg		询价
250 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

R419 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性
纯度 & 产品资料
参考文献

生物活性

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	19.5 μM Compound: R419	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 30001917]
A549	IC₅₀	> 20 μM Compound: 40	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]
C2C12	EC₅₀	0.23 μM Compound: 2, R419	Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	EC₅₀	0.03 μM Compound: 2, R419	Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	IC₅₀	2.817 μM Compound: 4; R419	Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production	[PMID: 38079537]
HepG2	IC₅₀	5.2 μM Compound: R419	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30001917]
L02	IC₅₀	25.9 μM Compound: R419	Cytotoxicity against human L02 cells after 72 hrs by MTT assay Cytotoxicity against human L02 cells after 72 hrs by MTT assay	[PMID: 30001917]
NCI-H1299	IC₅₀	> 20 μM Compound: 40	Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]

分子量

565.66

Formula

C₃₃H₃₅N₅O₄

CAS 号

1356629-00-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Huang Y, et al. Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2957-2960. [Content Brief]

R419 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R4191356629-00-9R 419R-419Oxidative PhosphorylationHepG2anti-cancerInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
粤ICP备2021105330号-3 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

R419

Customer Review

R419 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

R419 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

产品名称：			* Lot #：
* 客户姓名：			* Email：
电话：			* 部门：
* 公司或机构名称：
留言给我们：

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

R419

Customer Review

R419 相关抗体

R419 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

纯度 & 产品资料

参考文献

R419 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

Request for HNMR Report

Request for HNMR Report

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z