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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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K562 cell extracts

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By Targets:	Apoptosis (1) CDK (1) COX (1) DNA/RNA Synthesis (1) Interleukin Related (1) NO Synthase (1) P-glycoprotein (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

抑制剂 & 激动剂

天然产物

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Targets Recommended: Programmed Cell Death 4 (PDCD4) Itk TOPK NAMPT GDNF Receptor ALCAM/CD166 BCL6 Tim3 VISTA BMI1

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-153736

NSC 194308	DNA/RNA Synthesis Apoptosis	Cancer
NSC 194308 是一种 U2AF2-RNA 结合增强剂。NSC 194308 可增强 U2AF1^S34F-U2AF2-SF1 三元复合物与 DEK 剪接位点 RNA 的结合作用。NSC 194308 可通过在 U2AF 协助招募 U2 snRNP 至分支点的阶段阻滞剪接体组装，从而抑制前体 mRNA 剪接。NSC 194308 可增强前体 mRNA 与 U2AF2 的结合，在含有剪接体突变的白血病细胞系中选择性诱导细胞凋亡 (aptptosis) 与死亡。NSC 194308 可用于白血病的相关研究。

HY-W419589

Xanthomicrol	COX NO Synthase Interleukin Related Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
黄姜味草醇 Xanthomicrol 是从菝葜 (玄参科) 的树脂中提取的，是单胺氧化酶 (MAOs) 抑制剂。Xanthomicrol 有抗肿瘤活性和抗炎活性，在 HL60，K562 细胞中的 IC₅₀ 为 0.88，1.69 μg/mL。Xanthomicrol 是 5DT 在小鼠结肠中的主要代谢物，可降低 iNOS 蛋白和 mRNA 水平以及 COX-2 蛋白水平，还能降低促炎细胞因子 IL-1β 的产生，诱导抗氧化酶 HO-1 的表达。

HY-N1691

21-Episerratriol 3-Epilycoclavanol	Others	Cancer
21-表山芝烯三醇 3-Epilycoclavanol (3-Epilycoclavanol) 是一种三萜类抗肿瘤剂，能够从 Lycopodium japonicum (石松科石松属植物日本石松) 的干燥全株中提取得到。3-Epilycoclavanol 在 10-100 μg/mL 浓度下对人肿瘤 A549 和 K562 细胞系有抑制作用。

HY-N17005

3-O-(p-Hydroxybenzoyl)serratriol	Others	Cancer
3-O-(p-Hydroxybenzoyl)serratriol 是一种 serratene 型三萜类化合物，抗癌细胞的细胞毒性低 (对 K562、SMMC-7721、SGC7901 三种人癌细胞的 IC₅₀ >100 μg/mL)。3-O-(p-Hydroxybenzoyl)serratriol 能够从 Palhinhaea cernua 的全株中天然提取得到。

HY-N16684

Clausarin	P-glycoprotein	Cancer
黄皮香豆精 Clausarin 是 P-糖蛋白 (P-gp) 的选择性抑制剂，抑制 P-gp 介导的药物外排作用。Clausarin 在过表达 P-gp 的 K562/R7 人白血病细胞中可显著抑制 Daunorubicin (HY-13062A) 外排 (以 Cyclosporin A (HY-B0579) 为阳性对照)。Clausarin 能够从 Citrus sinensis (甜橙) 的根中天然提取得到，可用于克服肿瘤多药耐药 (MDR) 的相关研究。

HY-114567

GW780056X	CDK	Neurological Disease Metabolic Disease
GW780056X 是一种 CDK12 抑制剂。GW780056X 可降低 DM1 细胞中的核灶数量。GW780056X 可用于 1 型强直性肌营养不良的研究。

21-Episerratriol 3-Epilycoclavanol	Lycopodiaceae Structural Classification Triterpenes Terpenoids Plants Lycopodium japonicum Thunb. ex Murray Source Classification	Others
21-表山芝烯三醇 3-Epilycoclavanol (3-Epilycoclavanol) 是一种三萜类抗肿瘤剂，能够从 Lycopodium japonicum (石松科石松属植物日本石松) 的干燥全株中提取得到。3-Epilycoclavanol 在 10-100 μg/mL 浓度下对人肿瘤 A549 和 K562 细胞系有抑制作用。

3-O-(p-Hydroxybenzoyl)serratriol	Lycopodiaceae Structural Classification Palhinhaea cernua (L.) Vasc. & Franco Terpenoids Phenols Plants Pentacyclic Triterpenoids Source Classification	Others
3-O-(p-Hydroxybenzoyl)serratriol 是一种 serratene 型三萜类化合物，抗癌细胞的细胞毒性低 (对 K562、SMMC-7721、SGC7901 三种人癌细胞的 IC₅₀ >100 μg/mL)。3-O-(p-Hydroxybenzoyl)serratriol 能够从 Palhinhaea cernua 的全株中天然提取得到。

Clausarin	Structural Classification Rutaceae Coumarins Phenylpropanoids Plants Citrus sinensis (L.) Osbeck Source Classification	P-glycoprotein
黄皮香豆精 Clausarin 是 P-糖蛋白 (P-gp) 的选择性抑制剂，抑制 P-gp 介导的药物外排作用。Clausarin 在过表达 P-gp 的 K562/R7 人白血病细胞中可显著抑制 Daunorubicin (HY-13062A) 外排 (以 Cyclosporin A (HY-B0579) 为阳性对照)。Clausarin 能够从 Citrus sinensis (甜橙) 的根中天然提取得到，可用于克服肿瘤多药耐药 (MDR) 的相关研究。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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