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Oral controlled release

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By Targets:	Biochemical Assay Reagents (1) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) GLP Receptor (1) Keap1-Nrf2 (2) Liposome (1) Melanocortin Receptor (1) Reference Standards (1)
By Research Areas:	Cancer (2) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (2)
Oligonucleotides:	表面活性剂 (1) 磷脂 (1) 乳化剂 (1)

抑制剂 & 激动剂

生化试剂

寡核苷酸

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-42990

Hydrogenated soya phosphatidylcholine HSPC; Hydrogenated soybean phosphatidylcholine	Liposome	Metabolic Disease
Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) 是一种天然产物。Hydrogenated soya phosphatidylcholine 在药物负荷和溶解度方面可以延长药物释放，用于水溶性药物的口服给药

HY-106539

Colesevelam hydrochloride	FXR G protein-coupled Bile Acid Receptor 1 GLP Receptor	Metabolic Disease Cancer
Colesevelam hydrochloride 是一种具有口服活性的胆汁酸螯合剂、调脂剂和血糖控制剂。Colesevelam hydrochloride 可结合胃肠道中的胆汁酸形成不可吸收的复合物，中断肠肝循环并增加粪便胆汁酸的排泄。Colesevelam hydrochloride 可调控 FXR、TGR5 和 Cyp7a1 的活性，触发 cAMP 信号传导并促进 GLP-1 的释放。Colesevelam hydrochloride 可改变肝脏脂质和葡萄糖代谢，抑制肝糖原分解，降低肝脏甘油三酯和胆固醇水平，并加快 LDL-C 低密度脂蛋白胆固醇的清除。Colesevelam hydrochloride 可用于 2 型糖尿病、高胆固醇血症和酒精相关性肝病的研究。

HY-100375

Diroximel fumarate 4 篇文献验证 ALKS 8700; BIIB098	Keap1-Nrf2	Inflammation/Immunology
Diroximel fumarate (ALKS 8700) 是一种具有口服活性的富马酸单乙酯 (MMF) 的前体活性分子，为一种控释制剂。Diroximel fumarate 被认为与其活性代谢物富马酸二甲酯 (DMF) 的活性等效。Diroximel fumarate 具有良好的安全性和有效性，有用于多发性硬化 (MS) 研究的潜力。Diroximel fumarate 是一种 Nrf2 激活剂，可缓解 MGO 引起的疼痛超敏反应。

HY-W129513

Sorbitan monopalmitate	Biochemical Assay Reagents	Others
司本40 Sorbitan monopalmitate 是一种食品级非离子型乳化剂，具有口服活性。Sorbitan monopalmitate 可作为结晶调节剂，促进球形芒果脂晶体聚集，引入晶格缺陷，并调控芒果脂的结晶速率。Sorbitan monopalmitate 可作为前体囊泡凝胶的组分，实现药物的控释与缓释，并有助于制备稳定的透皮给药制剂。

HY-172299

Delmadinone acetate	Melanocortin Receptor	Endocrinology
醋酸地马孕酮 Delmadinone acetate 是一种口服活性化合物，可以控制雌性和雄性宠物的发情和排卵。Delmadinone acetate 通过抑制垂体释放 ACTH 引起肾上腺抑制。

HY-W721612

Bromebric acid	Others	Cancer
Bromebric acid 是一种一种具有细胞抑制和抗肿瘤活性的溴酸丙烯酸衍生物，可与氨基葡萄糖形成离子复合物以实现控释口服给药。

HY-100375R

Diroximel fumarate (Standard)	Reference Standards Keap1-Nrf2	Inflammation/Immunology
Diroximel fumarate (Standard) 是 Diroximel fumarate (HY-100375) 的分析标准品。本产品用于研究及分析应用。Diroximel fumarate (ALKS 8700) 是一种具有口服活性的富马酸单乙酯 (MMF) 的前体活性分子，为一种控释制剂。Diroximel fumarate 被认为与其活性代谢物富马酸二甲酯 (DMF) 的活性等效。Diroximel fumarate 具有良好的安全性和有效性，有用于多发性硬化 (MS)

Cat. No.	Product Name	Type

HY-42990

Hydrogenated soya phosphatidylcholine HSPC; Hydrogenated soybean phosphatidylcholine	Biochemical Assay Reagents
Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) 是一种天然产物。Hydrogenated soya phosphatidylcholine 在药物负荷和溶解度方面可以延长药物释放，用于水溶性药物的口服给药

Cat. No.	Product Name		Classification

HY-42990

Hydrogenated soya phosphatidylcholine HSPC; Hydrogenated soybean phosphatidylcholine		磷脂
Hydrogenated soya phosphatidylcholine (hydrogenated soybean phosphatidylcholine) 是一种天然产物。Hydrogenated soya phosphatidylcholine 在药物负荷和溶解度方面可以延长药物释放，用于水溶性药物的口服给药

HY-W129513

Sorbitan monopalmitate		乳化剂表面活性剂
Sorbitan monopalmitate 是一种食品级非离子型乳化剂，具有口服活性。Sorbitan monopalmitate 可作为结晶调节剂，促进球形芒果脂晶体聚集，引入晶格缺陷，并调控芒果脂的结晶速率。Sorbitan monopalmitate 可作为前体囊泡凝胶的组分，实现药物的控释与缓释，并有助于制备稳定的透皮给药制剂。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Oral controlled release

抑制剂 & 激动剂

生化试剂

寡核苷酸

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