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PKC activator 1

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By Targets:	PKC (8) Apoptosis (1) Autophagy (1) Cholinesterase (ChE) (1) Endogenous Metabolite (3) HIV (1) NF-κB (1) Parasite (1) Phosphatase (3) RABV (1) Reference Standards (1) SphK (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	磷脂 (1)

抑制剂 & 激动剂

生化试剂

天然产物

同位素标记物

寡核苷酸

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Targets Recommended: PKC

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 最多引用文献 726 篇文献验证 PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Neurological Disease Inflammation/Immunology Cancer
佛波酯 Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate) 是一种佛波酯，是蛋白激酶 C *(PKC)* 和 SphK 的激活剂。Phorbol 12-myristate 13-acetate 是 NF-κB 激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP-1 细胞分化 (已经经过 MCE 专业的生物实验验证)。

HY-101047

D-erythro-Sphingosine 4 篇文献验证 Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	PKC Phosphatase Endogenous Metabolite	Cancer
鞘氨醇 D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (*PKC)。D-erythro-Sphingosine (Erythrosphingosine) 也是一种 PP2A* 激活剂。

HY-18980

Rottlerin 20 篇以上引用文献 Mallotoxin; NSC 56346; NSC 94525	PKC Autophagy Apoptosis HIV RABV	Infection Cancer
Rottlerin 是可从 Mallotus Philippinensis 中分到的一种天然产物，是 PKC 的一个特异性抑制剂，其对 PKCδ 的 IC₅₀ 值为 3-6 μM， PKCα，β，γ 的为 30-42 μM，PKCε，η，ζ 为 80-100 μM。Rottlerin 可作为线粒体直接解偶联剂，通过靶向mTORC1 上游的信号级联刺激自噬。Rottlerin 通过活化 caspase 3 诱导细胞凋亡。Rottlerin 抑制 HIV-1 整合和狂犬病病毒 (RABV) 感染。

HY-128468

1,2-Dimyristoyl-sn-glycerol	PKC Cholinesterase (ChE) Parasite	Infection
1,2-Dimyristoyl-sn-glycerol 是一种蛋白激酶 C (protein kinase C) 激活剂。1,2-Dimyristoyl-sn-glycerol 可激活 PKC α。1,2-Dimyristoyl-sn-glycerol 可诱导曼氏血吸虫体内乙酰胆碱酯酶 (AChE) 活性升高。1,2-Dimyristoyl-sn-glycerol 可用于血吸虫病的研究。

HY-179090

**PKC activator-1**	PKC	Cancer
PKC activator-1 (compound 26) 是一种 *PKC* 激活剂 (K_i = 1.2 nM)。PKC activator-1 对多种癌细胞显示出细胞毒性。PKC activator-1 常用于癌症的研究。

HY-101047S

D-erythro-Sphingosine-d7 1 篇文献验证 Erythrosphingosine-d₇; erythro-C18-Sphingosine-d₇; trans-4-Sphingenine-d₇	PKC Phosphatase Endogenous Metabolite	Cancer
D-赤式鞘氨醇 d₇ D-erythro-Sphingosine-d₇ 是 D-erythro-Sphingosine 的氘代物。D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (*PKC*)。D-erythro-Sphingosine (Erythrosphi

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Reference Standards PKC Phosphatase Endogenous Metabolite	Cancer
鞘氨醇 (标准品) D-erythro-Sphingosine (Standard)是 D-erythro-Sphingosine 的分析标准品。本产品用于研究及分析应用。D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (*PKC*)。D-erythro-Sphingosine (Erythrosphing

HY-129330

Sapintoxin D	PKC	Others
Sapintoxin D 是一种荧光佛波醇酯，可用于研究蛋白激酶 C (PKC) 的活化。Sapintoxin D 是一种钙依赖性 PKC 激活剂。

Cat. No.	Product Name	Type

HY-128468

1,2-Dimyristoyl-sn-glycerol	Biochemical Assay Reagents
1,2-Dimyristoyl-sn-glycerol 是一种蛋白激酶 C (protein kinase C) 激活剂。1,2-Dimyristoyl-sn-glycerol 可激活 PKC α。1,2-Dimyristoyl-sn-glycerol 可诱导曼氏血吸虫体内乙酰胆碱酯酶 (AChE) 活性升高。1,2-Dimyristoyl-sn-glycerol 可用于血吸虫病的研究。

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 最多引用文献 726 篇文献验证 PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology Source Classification	PKC SphK NF-κB
佛波酯 Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate) 是一种佛波酯，是蛋白激酶 C *(PKC)* 和 SphK 的激活剂。Phorbol 12-myristate 13-acetate 是 NF-κB 激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP-1 细胞分化 (已经经过 MCE 专业的生物实验验证)。

HY-101047

D-erythro-Sphingosine 4 篇文献验证 Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Phosphatase Endogenous Metabolite
鞘氨醇 D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (*PKC)。D-erythro-Sphingosine (Erythrosphingosine) 也是一种 PP2A* 激活剂。

HY-18980

Rottlerin 20 篇以上引用文献 Mallotoxin; NSC 56346; NSC 94525	Structural Classification Flavonoids Chalcones Classification of Application Fields Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Source Classification Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin 是可从 Mallotus Philippinensis 中分到的一种天然产物，是 PKC 的一个特异性抑制剂，其对 PKCδ 的 IC₅₀ 值为 3-6 μM， PKCα，β，γ 的为 30-42 μM，PKCε，η，ζ 为 80-100 μM。Rottlerin 可作为线粒体直接解偶联剂，通过靶向mTORC1 上游的信号级联刺激自噬。Rottlerin 通过活化 caspase 3 诱导细胞凋亡。Rottlerin 抑制 HIV-1 整合和狂犬病病毒 (RABV) 感染。

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards PKC Phosphatase Endogenous Metabolite
鞘氨醇 (标准品) D-erythro-Sphingosine (Standard)是 D-erythro-Sphingosine 的分析标准品。本产品用于研究及分析应用。D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (*PKC*)。D-erythro-Sphingosine (Erythrosphing

HY-129330

Sapintoxin D	Natural Products Euphorbiaceae Plants Shirakiopsis indica (Willd.) Esser Source Classification	PKC
Sapintoxin D 是一种荧光佛波醇酯，可用于研究蛋白激酶 C (PKC) 的活化。Sapintoxin D 是一种钙依赖性 PKC 激活剂。

Cat. No.	Product Name	Chemical Structure

HY-101047S

D-erythro-Sphingosine-d7 1 篇文献验证
D-erythro-Sphingosine-d₇ 是 D-erythro-Sphingosine 的氘代物。D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC₅₀ 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (*PKC*)。D-erythro-Sphingosine (Erythrosphi

Cat. No.	Product Name		Classification

HY-128468

1,2-Dimyristoyl-sn-glycerol		磷脂
1,2-Dimyristoyl-sn-glycerol 是一种蛋白激酶 C (protein kinase C) 激活剂。1,2-Dimyristoyl-sn-glycerol 可激活 PKC α。1,2-Dimyristoyl-sn-glycerol 可诱导曼氏血吸虫体内乙酰胆碱酯酶 (AChE) 活性升高。1,2-Dimyristoyl-sn-glycerol 可用于血吸虫病的研究。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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PKC activator 1

抑制剂 & 激动剂

生化试剂

天然产物

同位素标记物

寡核苷酸

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