赭曲霉毒素 A
Ochratoxin A 是一种可穿透血脑屏障的食源性真菌毒素，是曲霉属 (Aspergillus) 和青霉属 (Penicillium) 真菌的次生代谢产物，属于 2B 类致癌物。Ochratoxin A 诱导氧化应激、抑制线粒体呼吸、造成氧化性 DNA 损伤、破坏 PPAR-γ-CD36 轴、诱导免疫抑制、介导线粒体依赖性凋亡 (apoptosis)、抑制谷氨酸吸收、引发脱髓鞘病变与神经炎症、导致 DNA 低甲基化及抑制细胞增殖等途径。Ochratoxin A 可诱发肾毒性、肝毒性、免疫毒性、神经毒性，还具有致突变性、致畸性与致癌性。
异烟棒曲霉素 C
Roquefortine C 是一种可以从 Penicillium species 中分离得到的霉菌毒素。Roquefortine C 是 P-gp 的激动剂，P450 3A 和 P450 1A 抑制剂。Roquefortine C 可抑制革兰氏阳性细菌，也具有一定的神经毒性。Roquefortine C 还可发挥抗肿瘤的活性。
球毛壳菌素 A
Chaetoglobosin A 是一种次级代谢产物、杀线虫剂。Chaetoglobosin A 可由 Penicillium aquamarinium 产生。Chaetoglobosin A 靶向细胞中的丝状肌动蛋白 (Filamentous actin)，从而诱导细胞周期阻滞，并抑制膜皱褶形成及细胞迁移。Chaetoglobosin A 优先诱导慢性淋巴细胞白血病细胞发生凋亡 (Apoptosis)。Chaetoglobosin A 可诱导南方根结线虫 (Meloidogyne incognita) J2 幼虫产生剂量和时间依赖性死亡。Chaetoglobosin A 可用于根结线虫病和慢性淋巴细胞白血病的相关研究。
Penipanoid C (Compound 9) 是一种 BRD4 抑制剂。Penipanoid C 可从源自海洋沉积物的真菌 Penicillium paneum SD-44 中分离得到。Penipanoid C 具有抗炎活性且对 SMMC-7721 细胞具有细胞毒活性。Penipanoid C 可用于炎症性疾病研究。
Remisporine B 是一种聚酮化合物，可从 Penicillium sp. ZJ-SY2 中分离得到。Remisporine B 具有免疫抑制活性，可以抑制 Concanavalin A (HY-P2149)-诱导的小鼠脾淋巴 T 细胞增殖和 LPS (HY-D1056)- 诱导的小鼠脾淋巴 B 细胞增殖，IC50 为 30.1 µg/mL 和 32.4 µg/mL。
Peniterphenyl A 是一种从深海衍生的青霉属植物中获得的天然产物。Peniterphenyl A 抑制 HSV-1/2 病毒进入细胞，并可能通过与病毒包膜糖蛋白 D 直接相互作用来干扰病毒吸附和膜融合，从而阻断 HSV-1/2 感染。Peniterphenyl A 是一种很有前途的抗 HSV-1/2 的先导化合物。
异烟棒曲霉素 C-13C22
Roquefortine C-13C22 是 13C 标记的 Roquefortine C (HY-N6748)。Roquefortine C 是一种可以从 Penicillium species 中分离得到的霉菌毒素。Roquefortine C 是 P-gp 的激动剂，P450 3A 和 P450 1A 抑制剂。Roquefortine C 可抑制革兰氏阳性细菌，也具有一定的神经毒性。Roquefortine C 还可发挥抗肿瘤的活性。
Echinoside A 是一种皂苷。Echinoside A 可从海参中分离得到。Echinoside A 抑制 Top2α 的催化活性，降低 Top2α 与 DNA 的非共价结合作用。Echinoside A 激活 Caspase-3 并诱导 PARP 裂解。Echinoside A 诱导细胞凋亡 (Apoptosis)。Echinoside A 对前列腺癌、肝细胞癌和 S-180 肉瘤具有抗癌活性。Echinoside A 对多种真菌表现出抗真菌 (antifungal) 活性，其最低生长抑制浓度范围为 3.12-50.0 μg/mL，包括对 Aspergillus 和 Penicillium 属真菌的强效活性。
Tsugaric acid A (Standard)是 Tsugaric acid A 的分析标准品。本产品用于研究及分析应用。Tsugaric acid A 可以显着抑制超氧阴离子的形成。Tsugaric acid A 还可以保护人类角质形成细胞免受紫外线 B (UVB) 诱导的损害。Tsugaric acid A 可以保护角质形成细胞免受光损伤。
异烟棒曲霉素 C
Roquefortine C 是一种可以从 Penicillium species 中分离得到的霉菌毒素。Roquefortine C 是 P-gp 的激动剂，P450 3A 和 P450 1A 抑制剂。Roquefortine C 可抑制革兰氏阳性细菌，也具有一定的神经毒性。Roquefortine C 还可发挥抗肿瘤的活性。
赭曲霉毒素 A
Ochratoxin A 是一种可穿透血脑屏障的食源性真菌毒素，是曲霉属 (Aspergillus) 和青霉属 (Penicillium) 真菌的次生代谢产物，属于 2B 类致癌物。Ochratoxin A 诱导氧化应激、抑制线粒体呼吸、造成氧化性 DNA 损伤、破坏 PPAR-γ-CD36 轴、诱导免疫抑制、介导线粒体依赖性凋亡 (apoptosis)、抑制谷氨酸吸收、引发脱髓鞘病变与神经炎症、导致 DNA 低甲基化及抑制细胞增殖等途径。Ochratoxin A 可诱发肾毒性、肝毒性、免疫毒性、神经毒性，还具有致突变性、致畸性与致癌性。
异烟棒曲霉素 C
Roquefortine C 是一种可以从 Penicillium species 中分离得到的霉菌毒素。Roquefortine C 是 P-gp 的激动剂，P450 3A 和 P450 1A 抑制剂。Roquefortine C 可抑制革兰氏阳性细菌，也具有一定的神经毒性。Roquefortine C 还可发挥抗肿瘤的活性。
球毛壳菌素 A
Chaetoglobosin A 是一种次级代谢产物、杀线虫剂。Chaetoglobosin A 可由 Penicillium aquamarinium 产生。Chaetoglobosin A 靶向细胞中的丝状肌动蛋白 (Filamentous actin)，从而诱导细胞周期阻滞，并抑制膜皱褶形成及细胞迁移。Chaetoglobosin A 优先诱导慢性淋巴细胞白血病细胞发生凋亡 (Apoptosis)。Chaetoglobosin A 可诱导南方根结线虫 (Meloidogyne incognita) J2 幼虫产生剂量和时间依赖性死亡。Chaetoglobosin A 可用于根结线虫病和慢性淋巴细胞白血病的相关研究。
Penipanoid C (Compound 9) 是一种 BRD4 抑制剂。Penipanoid C 可从源自海洋沉积物的真菌 Penicillium paneum SD-44 中分离得到。Penipanoid C 具有抗炎活性且对 SMMC-7721 细胞具有细胞毒活性。Penipanoid C 可用于炎症性疾病研究。
Remisporine B 是一种聚酮化合物，可从 Penicillium sp. ZJ-SY2 中分离得到。Remisporine B 具有免疫抑制活性，可以抑制 Concanavalin A (HY-P2149)-诱导的小鼠脾淋巴 T 细胞增殖和 LPS (HY-D1056)- 诱导的小鼠脾淋巴 B 细胞增殖，IC50 为 30.1 µg/mL 和 32.4 µg/mL。
Peniterphenyl A 是一种从深海衍生的青霉属植物中获得的天然产物。Peniterphenyl A 抑制 HSV-1/2 病毒进入细胞，并可能通过与病毒包膜糖蛋白 D 直接相互作用来干扰病毒吸附和膜融合，从而阻断 HSV-1/2 感染。Peniterphenyl A 是一种很有前途的抗 HSV-1/2 的先导化合物。
Tsugaric acid A (Standard)是 Tsugaric acid A 的分析标准品。本产品用于研究及分析应用。Tsugaric acid A 可以显着抑制超氧阴离子的形成。Tsugaric acid A 还可以保护人类角质形成细胞免受紫外线 B (UVB) 诱导的损害。Tsugaric acid A 可以保护角质形成细胞免受光损伤。
Echinoside A 是一种皂苷。Echinoside A 可从海参中分离得到。Echinoside A 抑制 Top2α 的催化活性，降低 Top2α 与 DNA 的非共价结合作用。Echinoside A 激活 Caspase-3 并诱导 PARP 裂解。Echinoside A 诱导细胞凋亡 (Apoptosis)。Echinoside A 对前列腺癌、肝细胞癌和 S-180 肉瘤具有抗癌活性。Echinoside A 对多种真菌表现出抗真菌 (antifungal) 活性，其最低生长抑制浓度范围为 3.12-50.0 μg/mL，包括对 Aspergillus 和 Penicillium 属真菌的强效活性。
Roquefortine C-13C22 是 13C 标记的 Roquefortine C (HY-N6748)。Roquefortine C 是一种可以从 Penicillium species 中分离得到的霉菌毒素。Roquefortine C 是 P-gp 的激动剂，P450 3A 和 P450 1A 抑制剂。Roquefortine C 可抑制革兰氏阳性细菌，也具有一定的神经毒性。Roquefortine C 还可发挥抗肿瘤的活性。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
