马兜铃酸 B
Aristolochic acid B (Aristolochic Acid II) 是一种口服活性的马兜铃酸 (AA) 主要成分。Aristolochic acid B 可从马兜铃属植物中分离。Aristolochic acid B 可形成 DNA 加合物。Aristolochic acid B 具有致突变性。Aristolochic acid B 在体内表现出比 Aristolochic acid I (HY-N0510) 更大的致癌风险。
Biotin Azide Plus 是一种集成了叠氮-生物素点击化学与光可切割连接臂功能的恶唑烷试剂。Biotin Azide Plus 既能与生物素硫醚反应生成稳定的亚磺酰亚胺产物，又能通过生物素氧化还原激活化学标记技术实现蛋白质与 DNA 的生物偶联。Biotin Azide Plus 利用链霉亲和素捕获结合光释放的特性，能够有效促进脂质来源亲电体蛋白质加合物的分离，从而广泛应用于 SKBR3 癌症等相关领域的科学研究。
3-CPs 是一种单官能团呋喃香豆素，和一种靶向金黄色葡萄球菌 DNA 的光保护剂，具有抗 UVB 致死活性。3-CPs 可竞争性嵌入DNA，在 UVB 照射下仅形成 4',5'-呋喃侧单加合物，并不可逆抑制环丁烷嘧啶二聚体形成。3-CPs 通过优先结合 DNA 的 (AT)n 强位点阻碍 UVB 诱导的 DNA 损伤，且不会成致死性的 DNA 链间交联；其诱导的少量单加合物可被细菌高效修复。3-CPs 可用于皮肤疾病光防护制剂的研发，以及细菌 DNA 光损伤修复机制和光化学疗法安全性优化的研究。
Sorocein H (Sanggenon P) 是一种桑属 Diels-Alder 型加合物 (MDAA)。Sorocein H 对酪氨酸酶 (tyrosinase) 具有抑制活性，其 IC50 值为 6.49 μM。Sorocein H 能够减少黑色素的生成。Sorocein H 可用于色素相关疾病的研究。
Antibiotic DC 81 (DC 81) 是一种由链霉菌种产生的抗肿瘤抗生素 (antitumor antibiotic)，是一种吡咯[2,1 -c][1,4]苯二氮平 (PBD)。Antibiotic DC 81 是核酸合成的有效抑制剂。Antibiotic DC 81 可以识别和结合特定的 DNA 序列，形成不稳定的共价加合物。
马兜铃酸 B (标准品)
Aristolochic acid B (Standard) 是 Aristolochic acid B (HY-N0511) 的分析标准品。本产品用于研究及分析应用。Aristolochic acid B (Aristolochic Acid II) 是一种口服活性的马兜铃酸 (AA) 主要成分。Aristolochic acid B 可从马兜铃属植物中分离。Aristolochic acid B 可形成 DNA 加合物。Aristolochic acid B 具有致突变性。Aristolochic acid B 在体内表现出比 Aristolochic acid I (HY-N0510) 更大的致癌风险。
Duocarmycin A 是一种具有广谱抗菌活性的抗肿瘤抗生素及 DNA 烷化剂，可作为有效载荷、合成抗体-药物偶联物 (ADC)。Duocarmycin A 能选择性结合富含 AT 的 DNA 小沟，通过烷化腺嘌呤 N3 残基形成共价加合物，从而破坏 DNA 结构并抑制其复制与转录。Duocarmycin A 可诱导细胞凋亡 (apoptosis)、亚 G1 期累积及染色质凝集，降低 pro-caspase-3/9 水平及诱导不依赖 p53 的 p21 表达。Duocarmycin A 被广泛应用于多种恶性肿瘤的研究，包括白血病、肉瘤、胶质母细胞瘤以及肺癌、乳腺癌、结直肠癌等多种实体瘤模型。
DILI 已被证实是一个由多种机制参与的复杂病理过程，其中包括肝脏的结构和功能完整性的直接损害（例如线粒体功能障碍）；产生改变肝细胞结构和功能的代谢产物；产生能与肝蛋白结合的反应性药物代谢产物，从而产生新的抗原性药物-蛋白质加合物，这些新的加合物被宿主的防御系统所针对（半抗原假说），并引发损害肝脏的全身超敏反应（即药物过敏）。
MCE 肝脏毒性化合物库包含 640 种肝脏毒性化合物，是进行肝损伤及相关药物毒理研究的有力工具，该化合物库也可以用来探究 DILI 发病机制，识别早期 DILI 标记物，在药物开发中及时发现并规避可能诱导肝损伤的药物设计，有助于药物的顺利上市。
Biotin Azide Plus 是一种集成了叠氮-生物素点击化学与光可切割连接臂功能的恶唑烷试剂。Biotin Azide Plus 既能与生物素硫醚反应生成稳定的亚磺酰亚胺产物，又能通过生物素氧化还原激活化学标记技术实现蛋白质与 DNA 的生物偶联。Biotin Azide Plus 利用链霉亲和素捕获结合光释放的特性，能够有效促进脂质来源亲电体蛋白质加合物的分离，从而广泛应用于 SKBR3 癌症等相关领域的科学研究。
马兜铃酸 B
Aristolochic acid B (Aristolochic Acid II) 是一种口服活性的马兜铃酸 (AA) 主要成分。Aristolochic acid B 可从马兜铃属植物中分离。Aristolochic acid B 可形成 DNA 加合物。Aristolochic acid B 具有致突变性。Aristolochic acid B 在体内表现出比 Aristolochic acid I (HY-N0510) 更大的致癌风险。
马兜铃酸 B (标准品)
Aristolochic acid B (Standard) 是 Aristolochic acid B (HY-N0511) 的分析标准品。本产品用于研究及分析应用。Aristolochic acid B (Aristolochic Acid II) 是一种口服活性的马兜铃酸 (AA) 主要成分。Aristolochic acid B 可从马兜铃属植物中分离。Aristolochic acid B 可形成 DNA 加合物。Aristolochic acid B 具有致突变性。Aristolochic acid B 在体内表现出比 Aristolochic acid I (HY-N0510) 更大的致癌风险。
Sorocein H (Sanggenon P) 是一种桑属 Diels-Alder 型加合物 (MDAA)。Sorocein H 对酪氨酸酶 (tyrosinase) 具有抑制活性，其 IC50 值为 6.49 μM。Sorocein H 能够减少黑色素的生成。Sorocein H 可用于色素相关疾病的研究。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
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