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sleep-wake cycle

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By Targets:	Cannabinoid Receptor (1) Drug Metabolite (1) MCHR1 (GPR24) (2) nAChR (1) Orexin Receptor (OX Receptor) (1)
By Research Areas:	Metabolic Disease (3) Neurological Disease (4)

抑制剂 & 激动剂

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-P1205A

MCH(human, mouse, rat) TFA 1 篇文献验证 Melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) TFA 是一种主要由下丘脑外侧区神经元合成的环状神经肽。MCH (human, mouse, rat) TFA 也是黑色素聚集激素受体 (MHC receptor) 的内源性配体，对人 MCH-1R 和 MCH-2R 的结合 IC₅₀ 为 0.3 nM 和 1.5 nM；功能性 EC₅₀ 值为 3.9 nM 和 88.7 nM。MCH (human, mouse, rat) TFA 不仅是促食欲信号，还是是能量稳态和睡眠-觉醒周期的关键整合与调节激素。MCH (human, mouse, rat) TFA 可用于肥胖、睡眠障碍等相关研究。

HY-P1205

MCH(human, mouse, rat) Melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) 是一种主要由下丘脑外侧区神经元合成的环状神经肽。MCH (human, mouse, rat) 也是黑色素聚集激素受体 (MHC receptor) 的内源性配体，对人 MCH-1R 和 MCH-2R 的结合 IC₅₀ 为 0.3 nM 和 1.5 nM；功能性 EC₅₀ 值为 3.9 nM 和 88.7 nM。MCH (human, mouse, rat) 不仅是促食欲信号，还是是能量稳态和睡眠-觉醒周期的关键整合与调节激素。MCH (human, mouse, rat) 可用于肥胖、睡眠障碍等相关研究。

HY-177085

Fumiporexant	Orexin Receptor (OX Receptor)	Neurological Disease
Fumiporexant (Compound Example 93) 是一种具有口服活性、脑渗透性且选择性的食欲素受体 2 (OX2R) 拮抗剂。Fumiporexant 调节中枢神经系统中的睡眠-觉醒周期以及与情绪相关的通路。Fumiporexant 有望用于神经系统疾病的研究，如失眠和重度抑郁症等。

HY-W587817

6-Sulfatoxymelatonin sodium	Drug Metabolite	Metabolic Disease
6-Sulfatoxymelatonin sodium salt 是褪黑素的代谢物。褪黑素是大脑松果腺自然产生的激素，参与调节睡眠-觉醒周期和昼夜节律。

HY-118056

ABD459	Cannabinoid Receptor
ABD459 是一种 CB1 受体拮抗剂，表现出显著的食物摄取调控和睡眠-觉醒周期调节作用。ABD459 可完全置换 CB1 激动剂 CP99540 (Ki 为 8.6 nM)，并可拮抗 CP55940 诱导的 GTPγS 结合 (K_B 为 7.7 nM)。ABD459 可能通过调节胆碱能活动，特异性影响内源性大麻素的释放，在注意力和觉醒调控中发挥重要作用。ABD459 可用于神经疾病领域研究。

HY-118751

Bensultap Bancol	nAChR	Others Neurological Disease
杀虫磺 Bensultap (Bancol) 是一种杀虫剂，可防治科罗拉多甲虫和其他一些害虫。Bensultap 是一种烟碱乙酰胆碱受体 (nAChR) 调节剂，对大鼠神经系统具有轻微且短暂的神经调节作用。

Cat. No.	Product Name	Target	Research Area

HY-P1205A

MCH(human, mouse, rat) TFA 1 篇文献验证 Melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) TFA 是一种主要由下丘脑外侧区神经元合成的环状神经肽。MCH (human, mouse, rat) TFA 也是黑色素聚集激素受体 (MHC receptor) 的内源性配体，对人 MCH-1R 和 MCH-2R 的结合 IC₅₀ 为 0.3 nM 和 1.5 nM；功能性 EC₅₀ 值为 3.9 nM 和 88.7 nM。MCH (human, mouse, rat) TFA 不仅是促食欲信号，还是是能量稳态和睡眠-觉醒周期的关键整合与调节激素。MCH (human, mouse, rat) TFA 可用于肥胖、睡眠障碍等相关研究。

HY-P1205

MCH(human, mouse, rat) Melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) 是一种主要由下丘脑外侧区神经元合成的环状神经肽。MCH (human, mouse, rat) 也是黑色素聚集激素受体 (MHC receptor) 的内源性配体，对人 MCH-1R 和 MCH-2R 的结合 IC₅₀ 为 0.3 nM 和 1.5 nM；功能性 EC₅₀ 值为 3.9 nM 和 88.7 nM。MCH (human, mouse, rat) 不仅是促食欲信号，还是是能量稳态和睡眠-觉醒周期的关键整合与调节激素。MCH (human, mouse, rat) 可用于肥胖、睡眠障碍等相关研究。

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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